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Cardiovascular Research 1998 39(2):312-317; doi:10.1016/S0008-6363(98)00138-2
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Endothelial function and myocardial infarction

Kiran Bhagat*

Cruciform Project for Strategic Medical Research, University College London, 5 University Street, London WC1E 6JJ, UK

* Tel.: 00 44 171 209 6616; Fax: 00 44 171 813 2846; E-mail: k.bhagat@ucl.ac.uk

Received 15 January 1998; accepted 17 April 1998

The first 150 words of the full text of this article appear below.


   1 Introduction
 
Several standard risk factors are now recognised for the development of coronary disease and a modulation of some of these factors has been shown to decrease the incidence and recurrence of coronary events [1–3]. Mortality in coronary disease is directly related to the number of diseased vessels, the presence of left ventricular dysfunction, and an ischaemic response on treadmill exercise testing. However, our ability to prognosticate based on an understanding of ischaemia or angiography still remains very poor. Furthermore, it is recognised that traditional antianginal therapy does not significantly alter prognosis; angioplasty does not prevent myocardial infarction or death on follow up and although by-pass surgery may decrease subsequent mortality in certain sub-groups, it has not been shown to decrease the future incidence of myocardial infarction [4, 5].

At least one important reason for this unpredictability is that acute ischaemic events, particularly myocardial infarction, are unrelated to stenosis . . . [Full Text of this Article]


   2 Endothelial dysfunction in myocardial infarction and unstable angina
 

   3 Endothelial dysfunction precipitating acute myocardial infarction?
 

   4 Therapeutic implications
 

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