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Cardiovascular Research 1998 39(1):8-33; doi:10.1016/S0008-6363(98)00108-4
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Mouse models of angiogenesis, arterial stenosis, atherosclerosis and hemostasis

Peter Carmeliet*, Lieve Moons and Désiré Collen

Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Leuven, B-3000, Belgium

* Corresponding author. Tel.: +32 (16) 345 772; Fax: +32 (16) 345 990; E-mail: peter.carmeliet@med.kuleuven.ac.be

The development of efficient transgenic technologies in mice has allowed the study of the consequences of genetic alterations on cardiovascular (patho)physiology, although the development of such models have been hampered by size limitation of species resulting in time-consuming, labor-intensive and costly analyses. This overview summarizes the murine models currently available for studying or manipulating angiogenesis, arterial stenosis, atherosclerosis, transplant arteriopathy, thrombosis, thrombolysis and bleeding and addresses techniques to evaluate vascular development during embryogenesis.

KEYWORDS Angiogenesis; Atherosclerosis; Restenosis; Bleeding; Thrombosis; Transplantation; Adenovirus


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