© 1998 by European Society of Cardiology
Copyright © 1998, European Society of Cardiology
The atherosclerotic Yucatan animal model to study the arterial response after balloon angioplasty: the natural history of remodeling
aDepartment of Cardiology, Utrecht University Hospital, Utrecht, Netherlands
bInteruniversity Cardiology Institute of the Netherlands, Utrecht, Netherlands
cCardiovascular Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
* Corresponding author: Tel.: 617 667 3790; Fax: 617 975 5201; E-mail: mpost@bidmc.harvard.edu
Objective: Remodeling in de novo atherosclerosis and in restenosis after balloon angioplasty constitutes a change in total arterial circumference which, together with plaque growth or neointimal formation, determines the lumen of the artery. To better understand the fundamental biology of neointimal formation, remodeling and their interaction, animal studies are needed. In this study, we described in detail the methodology used and the natural history of neointimal formation and remodeling after balloon angioplasty in atherosclerotic Yucatan micropigs. Methods and results: Atherosclerosis was induced in 60 peripheral arteries of sixteen Yucatan micropigs by a combination of denudation and atherogenic diet. Balloon angioplasty was performed in 38 arteries, with serial intravascular ultrasound (IVUS) and quantitative angiography before and after intervention and at 2, 4, 7, 14 or 42 days follow-up. Remodeling, expressed as late media-bounded area (MBA) loss, increased progressively over time. At 42 days, late MBA loss after balloon angioplasty was significantly different compared to late MBA loss in control arteries, 2.2±1.0 versus –0.3±1.1 mm2 and p=0.02. Late lumen loss increased over time and was highest at 42 days after balloon angioplasty (2.8±0.7 mm2). The contribution of neointimal formation to late lumen loss decreased over time and the contribution of late MBA loss to late lumen increased over time and was highest at 42 days (78%). Medial necrosis was 48% at two days after balloon angioplasty and the repopulation of the media was almost completed at seven days. Conclusion: Remodeling following balloon angioplasty has an early onset and progresses with neointimal formation to cause restenosis over the standard 42-day time course for Yucatan micropigs. This correlates to six months renarrowing in humans. In this model, atherosclerosis and the natural history of restenosis, both with respect to neointimal formation and remodeling, resemble the human disease quite closely.
KEYWORDS Experimental (discipline); Vasculature (object of study); Circulatory physiology (level); Remodeling; Angioplasty; Ultrasound; Arteries; Atherosclerosis (additional)
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M Maeng, L O Jensen, E Falk, H R Andersen, and L Thuesen Negative vascular remodelling after implantation of bioabsorbable magnesium alloy stents in porcine coronary arteries: a randomised comparison with bare-metal and sirolimus-eluting stents Heart, February 1, 2009; 95(3): 241 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Y.K. Lee, H.-F. Tse, C.-W. Siu, S.-G. Zhu, R. Y.K. Man, and P. M. Vanhoutte Genomic Changes in Regenerated Porcine Coronary Arterial Endothelial Cells Arterioscler Thromb Vasc Biol, November 1, 2007; 27(11): 2443 - 2449. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Fang, E. R. Mohler III, E. Hsieh, H. Osman, S. M. Hashemi, P. F. Davies, G. H. Rothblat, R. L. Wilensky, and I. Levitan Hypercholesterolemia Suppresses Inwardly Rectifying K+ Channels in Aortic Endothelium In Vitro and In Vivo Circ. Res., April 28, 2006; 98(8): 1064 - 1071. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Brasselet, E. Durand, F. Addad, A. A. H. Zen, M. B. Smeets, D. Laurent-Maquin, S. Bouthors, G. Bellon, D. de Kleijn, G. Godeau, et al. Collagen and elastin cross-linking: a mechanism of constrictive remodeling after arterial injury Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2228 - H2233. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Sindermann, P. Babij, J. C. Klink, C. Kobbert, G. Plenz, J. Ebbing, L. Fan, and K. L. March Smooth muscle-specific expression of SV40 large TAg induces SMC proliferation causing adaptive arterial remodeling Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2714 - H2724. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Pasterkamp, M. J. Sierevogel, D. P.V. de Kleijn, B. H. Strauss, R. L. Geary, and G. S. Cherr MMP Inhibition and Lumen Loss After Balloon Angioplasty or Stenting * In Response Arterioscler Thromb Vasc Biol, July 1, 2002; 22(7): 1241 - 1241. [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Sindermann, J. Smith, C. Kobbert, G. Plenz, A. Skaletz-Rorowski, J. L. Solomon, L. Fan, and K. L. March Direct evidence for the importance of p130 in injury response and arterial remodeling following carotid artery ligation Cardiovasc Res, June 1, 2002; 54(3): 676 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Schoenhagen, K. M. Ziada, D. G. Vince, S. E. Nissen, and E. M. Tuzcu Arterial remodeling and coronary artery disease: the concept of "dilated" versus "obstructive" coronary atherosclerosis J. Am. Coll. Cardiol., August 1, 2001; 38(2): 297 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. J. Wentzel, J. Kloet, I. Andhyiswara, J. A. F. Oomen, J. C. H. Schuurbiers, B. J. G. L. de Smet, M. J. Post, D. de Kleijn, G. Pasterkamp, C. Borst, et al. Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty : Effect of Matrix Metalloproteinase Inhibition Circulation, July 3, 2001; 104(1): 91 - 96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Orbe, J. A Rodriguez, A. Calvo, A. Grau, M. S Belzunce, D. Martinez-Caro, and J. A Paramo Vitamins C and E attenuate plasminogen activator inhibitor-1 (PAI-1) expression in a hypercholesterolemic porcine model of angioplasty Cardiovasc Res, February 1, 2001; 49(2): 484 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Sierevogel, G. Pasterkamp, E. Velema, P. P. T. de Jaegere, B. J. G. L. de Smet, J. H. Verheijen, D. P. V. de Kleijn, and C. Borst Oral Matrix Metalloproteinase Inhibition and Arterial Remodeling After Balloon Dilation : An Intravascular Ultrasound Study in the Pig Circulation, January 16, 2001; 103(2): 302 - 307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Pasterkamp, D. P.V de Kleijn, and C. Borst Arterial remodeling in atherosclerosis, restenosis and after alteration of blood flow: potential mechanisms and clinical implications Cardiovasc Res, March 1, 2000; 45(4): 843 - 852. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. J. Sierevogel, E. Velema, P. P. de Jaegere, D. P. de Kleijn, C. Borst, and G. Pasterkamp Minimal Duration of Oral Matrix Metalloproteinase Inhibition to Prevent Constrictive Arterial Remodeling after Balloon Dilation in the Pig Radiology, February 1, 2002; 222(2): 468 - 473. [Abstract] [Full Text] [PDF]
|
|