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Cardiovascular Research 1998 39(1):148-154; doi:10.1016/S0008-6363(98)00107-2
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Physio-pharmacological evaluation of myocardial performance: an integrative approach

Ajay M Shaha,*, Steven J Sollottb and Edward G Lakattab

aDepartment of Cardiology, University of Wales College of Medicine, Heath Park, Cardiff, CF4 FXN, UK
bLaboratory of Cardiovascular Science, Gerontology Research Center, NIA, National Institutes of Health, Baltimore, USA

* Corresponding author. Tel.: +44 1222 742338; Fax: +44 1222 743500; E-mail: shaham2@cf.ac.uk

Received 16 March 1998; accepted 17 March 1998

KEYWORDS Contractive function; Endothelial function; Myocytes; Ventricular function

The first 150 words of the full text of this article appear below.

Despite major advances in the understanding of cardiovascular physiology and pathophysiology and the development of new therapies in the 20th century, cardiovascular disease is projected to become the leading overall cause of mortality worldwide within the next couple of decades [1]. In the western world, an increasing proportion of older people in the population accounts for the lack of reduction in the absolute number of cardiovascular deaths, whereas in developing countries, part of the reason is the adoption of "western" lifestyles and their accompanying coronary risk factors as socioeconomic status gradually improves and mortality from infectious and other diseases of early life decrease. There remain significant gaps in our understanding of many aspects of cardiovascular diseases and the contribution of risk factors such as smoking, hypercholesterolaemia, hypertension and diabetes. In addition, increasing numbers of patients who survive ischaemic cardiac disorders develop heart failure.

Traditionally, the focus of research into . . . [Full Text of this Article]


   1 The isolated heart
 

   2 Isolated papillary muscle and trabecular preparations
 

   3 Isolated cardiac myocytes
 

   4 Subcellular model systems
 

   5 The use of animal models
 

   6 Conclusions
 

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