Skip Navigation

Cardiovascular Research 1998 38(2):493-499; doi:10.1016/S0008-6363(98)00016-9
© 1998 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Källner, G.
Right arrow Articles by Franco-Cereceda, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Källner, G.
Right arrow Articles by Franco-Cereceda, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1998, European Society of Cardiology

Calcitonin gene-related peptide in myocardial ischaemia and reperfusion in the pig

Göran Källnera,*, Adrian Gononb and Anders Franco-Cerecedaa

aDepartment of Thoracic Surgery, Karolinska Hospital, S-171 76 Stockholm, Sweden
bDepartment of Cardiology, Karolinska Hospital, S-171 76 Stockholm, Sweden

* Corresponding author. Tel.: +46 (8) 5177-3434; Fax: +46 (8) 322701.

Objective: In myocardial ischaemia, slow conducting capsaicin-sensitive C-fibres are activated. Apart from the mediation of pain, activation of these fibres causes release of various peptides, such as calcitonin gene-related peptide (CGRP), which is a potent vasodilator. The aim of this study was to investigate the role of CGRP in the context of myocardial ischaemia in vivo. Methods: The left anterior descending coronary artery (LAD) was occluded during 45 min in 27 anaesthetised open-chest pigs. LAD flow, mean arterial pressure (MAP), heart rate, peak dP/dt, arterial and coronary venous concentration of CGRP was measured prior to ischaemia, and during 4 h of reperfusion. The extent of myocardial infarction was measured using staining with triphenyl tetrazolium chloride. Results: Retroinfusion of CGRP (100 µg) into the ischaemic myocardium was associated with a more pronounced hyperaemia, and systemic hypotension, during early reperfusion. The infarct size in relation to the area at risk was not affected by CGRP or the CGRP antagonist CGRP(8–37), and averaged 67±3%. There were no changes in plasma CGRP levels during ischaemia or reperfusion. Conclusion: Exogenously administered CGRP can cause systemic hypotension and augments postischaemic coronary flow. In this model, no cardioprotective effect of CGRP could be proven.

KEYWORDS C fiber; CGRP; CGRP(8–37); Ischemia; Pig; Reperfusion


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Pharmacol. Exp. Ther.Home page
C. P. Regan, G. L. Stump, S. A. Kane, and J. J. Lynch Jr.
Calcitonin Gene-Related Peptide Receptor Antagonism Does Not Affect the Severity of Myocardial Ischemia during Atrial Pacing in Dogs with Coronary Artery Stenosis
J. Pharmacol. Exp. Ther., February 1, 2009; 328(2): 571 - 578.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. Huang, A. Karve, I. Shah, M. C. Bowers, D. J. DiPette, S. C. Supowit, and G. S. Abela
Deletion of the mouse {alpha}-calcitonin gene-related peptide gene increases the vulnerability of the heart to ischemia-reperfusion injury
Am J Physiol Heart Circ Physiol, March 1, 2008; 294(3): H1291 - H1297.
[Abstract] [Full Text] [PDF]

Home page
 Cardiovasc ResHome page
T. Strecker, K. Messlinger, M. Weyand, and P. W. Reeh
Role of different proton-sensitive channels in releasing calcitonin gene-related peptide from isolated hearts of mutant mice
Cardiovasc Res, February 1, 2005; 65(2): 405 - 410.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.