© 1998 by European Society of Cardiology
Copyright © 1998, European Society of Cardiology
A review of the actions and control of intracellular pH in vascular smooth muscle
aInstitute of Biomedical and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK
bDepartment of Medicine, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK
cPhysiological Laboratory, University of Liverpool, Liverpool, L69 3BX, UK
* Corresponding author. Tel.: +44 (141) 330-5963; Fax: +44 (141) 330-4612.
Objective: This review is an account of the physiological issues involved in the effects of pH on vascular smooth muscle tone. The following criteria were considered when reviewing the literature: (i) the type of smooth muscle, i.e. either tonic or phasic, (ii) the source of the smooth muscle i.e. pulmonary, systemic, large artery, resistance artery, vein or cell line, (iii) the effects of changing intracellular or extracellular pH alone, (iv) the acute or chronic effects of altered pH (v) the influence of extracellular pH on intracellular pH and (vi) the influence of altered intracellular pH on basal or agonist induced tone. Studies of the effects of pH on the individual intracellular components of vascular tone, specifically sarcoplasmic reticulum and contractile proteins function are considered. Finally, the pH sensitivity of molecular components that contribute to smooth muscle cell tone are reviewed. Conclusions: There appear to be distinct differences in the response of large arteries and resistance arteries to altered intracellular pH which may be based on the different properties of the smooth muscle within the wall of each blood vessel. Similarly, systemic and pulmonary vessels may respond differently, but no systematic study exists to allow a more definitive conclusion. Factors controlling intracellular pH such as intracellular buffering power and sarcolemmal pH regulating mechanisms may differ across the vascular bed and may contribute to some of the differences observed in response to altered extracellular pH. Finally, few studies have examined the pH sensitivity the intracellular processes involved in basal tone and pharmaco-mechanical coupling in vascular smooth muscle. More information concerning these latter aspects of smooth muscle function is required to progress the understanding of the modulator action of pH on vascular tone.
KEYWORDS pH; Arteries; Veins; Smooth muscle; Intra/extracellular ions
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. J. Ray and J. M. Marshall Nitric oxide (NO) does not contribute to the generation or action of adenosine during exercise hyperaemia in rat hindlimb J. Physiol., April 1, 2009; 587(7): 1579 - 1591. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. D. Shah Effects of modulators of TASK potassium channels on rat pulmonary artery tone Bioscience Horizons, June 1, 2008; 1(2): 114 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. P. Smith, R. A. Dombkowski, J. T. Wincko, and K. R. Olson Effect of pH on trout blood vessels and gill vascular resistance J. Exp. Biol., July 1, 2006; 209(13): 2586 - 2594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Boedtkjer, J. Praetorius, and C. Aalkjaer NBCn1 (slc4a7) Mediates the Na+-Dependent Bicarbonate Transport Important for Regulation of Intracellular pH in Mouse Vascular Smooth Muscle Cells Circ. Res., March 3, 2006; 98(4): 515 - 523. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Kluess, J. B. Buckwalter, J. J. Hamann, and P. S. Clifford Elevated temperature decreases sensitivity of P2X purinergic receptors in skeletal muscle arteries J Appl Physiol, September 1, 2005; 99(3): 995 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. A. Kluess, J. B. Buckwalter, J. J. Hamann, and P. S. Clifford Acidosis attenuates P2X purinergic vasoconstriction in skeletal muscle arteries Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H129 - H132. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Steendahl, N.-H. Holstein-Rathlou, C. M. Sorensen, and M. Salomonsson Effects of chloride channel blockers on rat renal vascular responses to angiotensin II and norepinephrine Am J Physiol Renal Physiol, February 1, 2004; 286(2): F323 - F330. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. K. Rohra, T. Yamakuni, K.-I. Furukawa, N. Ishii, T. Shinkawa, T. Isobe, and Y. Ohizumi Stimulated Tyrosine Phosphorylation of Phosphatidylinositol 3-Kinase Causes Acidic pH-Induced Contraction in Spontaneously Hypertensive Rat Aorta J. Pharmacol. Exp. Ther., December 1, 2002; 303(3): 1255 - 1264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. D. Smith, D. A. Eisner, and S. Wray pH-induced changes in calcium: functional consequences and mechanisms of action in guinea pig portal vein Am J Physiol Heart Circ Physiol, December 1, 2002; 283(6): H2518 - H2526. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D.A. Kregenow and E.R. Swenson The lung and carbon dioxide: implications for permissive and therapeutic hypercapnia Eur. Respir. J., July 1, 2002; 20(1): 6 - 11. [Full Text] [PDF]
|
|
|
|
|
|
G Knock, D Psaroudakis, S Abbot, and P I Aaronson Propionate-induced relaxation in rat mesenteric arteries: a role for endothelium-derived hyperpolarising factor J. Physiol., February 1, 2002; 538(3): 879 - 890. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Taniguchi, R. Inagaki, F. Suzuki, and I. Muramatsu Rapid acid extrusion response triggered by {alpha}1 adrenoceptor in CHO cells J. Physiol., August 15, 2001; 535(1): 107 - 113. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Loutzenhiser and R. Loutzenhiser Angiotensin II-Induced Ca2+ Influx in Renal Afferent and Efferent Arterioles : Differing Roles of Voltage-Gated and Store-Operated Ca2+ Entry Circ. Res., September 29, 2000; 87(7): 551 - 557. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Austin and S. Wray Interactions Between Ca2+ and H+ and Functional Consequences in Vascular Smooth Muscle Circ. Res., February 18, 2000; 86(3): 355 - 363. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Leach, D. W. Sheehan, V. P. Chacko, and J. T. Sylvester Energy state, pH, and vasomotor tone during hypoxia in precontracted pulmonary and femoral arteries Am J Physiol Lung Cell Mol Physiol, February 1, 2000; 278(2): L294 - L304. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Otter and C. Austin Mechanisms of hypoxic vasodilatation of isolated rat mesenteric arteries: a comparison with metabolic inhibition J. Physiol., April 1, 1999; 516(1): 249 - 259. [Abstract] [Full Text] [PDF]
|
|