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Cardiovascular Research 1998 38(1):133-139; doi:10.1016/S0008-6363(97)00297-6
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Sodium nitroprusside enhances in vivo left ventricular function in β-adrenergically stimulated rabbit hearts

Peter A De Muldera, Stefan G De Herta,*, Roeland J Van Kerckhovenb, Hugo F Adriaensena and Thierry C Gillebertc

aDepartment of Anesthesiology, University of Antwerp, Antwerp, Belgium
bDepartment of Experimental Surgery, University of Antwerp, Antwerp, Belgium
cDepartment of Cardiology, University of Antwerp, Antwerp, Belgium

* Corresponding author. Department of Anesthesiology, University Hospital Antwerp, Wilrijkstraat 10, B-2650 Edegem, Belgium. Tel.: +32 (3) 821-3042; Fax: +32 (3) 825-0594; E-mail: sdehert@uia.ac.be

Objective: Sodium nitroprusside (SNP) is an activator of soluble guanylate cyclase, which depresses myocardial contractility. These exclusively negative inotropic effects of SNP were recently challenged by in vitro data. In isolated rat ventricular myocytes, a moderate increase of cGMP improved the contractile response at baseline and in isoprenaline-stimulated conditions. The present study evaluated in vivo the inotropic effects of SNP at baseline and during administration of low dose dobutamine. Methods: Anesthetized open-chest rabbits (n=18) were instrumented with micromanometers, ultrasound crystals and atrial pacing wires. Measurements were obtained during caval occlusion with ventilation suspended at end-expiration. Systolic function was assessed with dP/dtmax and the slope Ees of the end-systolic pressure–volume relation. Diastolic function was assessed with the time constant {tau} and the stiffness constant Kc of the diastolic pressure–volume relation. SNP (0.02, 0.08, 0.32 µg·kg–1·min–1) was administered at baseline and during low dose dobutamine. Results: At baseline, SNP reduced dP/dtmax from 3750±88 to 3470±88 mmHg/s (mean±s.e.m.) and Ees from 148±16 to 103±13 mmHg/ml (P<0.01). During dobutamine infusion, SNP increased dP/dtmax from 4340±125 to 4681±230 mmHg/s and Ees from 148±19 to 190±30 mmHg/ml (P<0.01). Effects of SNP on dP/dtmax and Ees were different at baseline and during dobutamine (interaction P<0.01). SNP did not alter Kc at baseline nor during dobutamine. Conclusions: SNP enhances in vivo systolic function in β-adrenergically stimulated rabbits.

KEYWORDS Rabbit; Sodium nitroprusside; Dobutamine; Systolic; Diastolic; Ventricular function


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