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Cardiovascular Research 1998 37(2):335-345; doi:10.1016/S0008-6363(97)00261-7
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Human myocardial Na,K-ATPase — quantification, regulation and relation to Ca

Thomas A Schmidt* and Keld Kjeldsen

Department of Medicine B 2142, The Heart Center, Rigshospitalet, Blegdamsvej 9, 2100 Copenhagen, Denmark

* Corresponding author. Tel. (+45) 3545 2871; Fax: (+45) 3138 3186.

Received 14 August 1997; accepted 17 October 1997

The first 150 words of the full text of this article appear below.


   1 The Na,K-ATPase
 
The Na,K-ATPase (sodium, potassium adenosine triphosphatase) or the Na,K-pump is an ubiquitous enzyme which performs the active transport of Na and K across the cell membrane [1]. Thus, by hydrolysing ATP the Na,K-ATPase pumps 3 Na ions out of the cell and 2 K ions into the cell. Hence, Na,K-ATPase is of importance for the characteristic distribution of these cations across the cell membrane and for generation of the membrane potential; thus optimum Na,K-ATPase function is required to ensure excitability and conduction. By generating the Na gradient across the sarcolemma, Na,K-ATPase creates a driving force for active Ca extrusion via the Na — Ca exchanger embedded in the membrane. Together with the Ca-ATPase located in the sarcolemma and in the membrane of the sarcoplasmic reticulum, the Na-Ca exchanger is of importance for maintaining low diastolic Ca concentration [2]. When muscular cells are depolarized intracellular Ca rises as much . . . [Full Text of this Article]


   2 Na,K-ATPase quantification
 

   3 Normal human myocardial Na,K-ATPase concentration
 

   4 Human myocardial Na,K-ATPase concentration changes in heart disease
 

   5 Normal human skeletal muscle Na,K-ATPase concentration
 

   6 Human skeletal muscle Na,K-ATPase concentration changes in heart disease
 

   7 Digitalization and muscular Na,K-ATPase
 

   8 Conclusions and clinical perspectives
 

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