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Cardiovascular Research 1998 37(1):236-238; doi:10.1016/S0008-6363(97)00219-8
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

A new heart failure model in rat by an end-to-side femoral vessel anastomosis

Cuneyt Ozeka, Feng Zhanga,b, William C Lineaweavera,*, Brian T Chinb, Thomas Eimanc, Leonard Newlinb and Harry J Bunckeb

aDivision of Plastic and Reconstructive Surgery, Stanford University Medical Center, NC 104, Stanford, CA 94305, USA
bMicrosurgical Replantation-Transplantation Service, Davies Medical Center, San Francisco, CA, USA
cDepartment of Pathology, Davies Medical Center, San Francisco, CA, USA

* Corresponding author. Tel. (+1-415) 723 5824; Fax: (+1-415) 725 6605.

Objective: The aim of this study was to develop a new shunting procedure for producing heart failure in the rat incorporating microvascular techniques and avoiding an abdominal operation. Method: We performed an end-to-side anastomosis between the femoral vein and the femoral artery just proximal to their trifurcation into the saphenous, epigastric, and distal femoral vessels. Results: Of the 15 rats which underwent this procedure, six died within 48 h. The nine surviving animals were sacrificed and examined six weeks following surgery. All nine had developed cardiac hypertrophy and cardiac failure. Conclusion: This model provides a relatively simple and reproducible means of creating high output heart failure and cardiac hypertrophy in the rat without necessitating abdominal surgery.

KEYWORDS Microsurgery; Rat; Cardiac failure; Arteriovenous shunt

1 (The vessel is occluded with forceps distal to the anastomosis. Another forceps is placed just distal to the first and the vessel is milked for several mm away from the anastomosis. The emptied vessel is occluded at this point and the proximal forceps is released. Rapid filling is seen from proximal to distal)


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