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Cardiovascular Research 1998 37(1):202-209; doi:10.1016/S0008-6363(97)00210-1
© 1998 by European Society of Cardiology
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Copyright © 1998, European Society of Cardiology

Effects of norepinephrine on expression of IGF-1/IGF-1R and SERCA2 in rat heart

XiWu Sun and Yuk-Chow Ng*

Department of Pharmacology, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA

* Corresponding author. Tel. +1-717-531-6027; Fax +1-717-531-5013.

Objectives: The effects of norepinephrine on expression of cardiac genes during pathological cardiac growth and heart failure are not fully understood. Tissue insulin-like growth factor 1 (IGF-1) and its receptor (IGF-1R) play an important role in the regulation of the hyperplastic capacity of cardiac myocytes. Sarcoplasmic reticulum Ca2+-ATPase (SERCA2), on the other hand, is important in regulating cardiac contractile function. The present study examined the effects of elevated levels of NE on expression of IGF-1/IGF-1R and SERCA2 mRNAs. Methods: Rats were infused with NE using osmotic minipumps for 3 and 6 days at a rate of 50 µg/kg/h and also at a higher dose (130 µg/kg/h) for 6 and 14 days. Levels of expression of IGF-1/IGF-1R and SERCA2 mRNAs were determined by ribonuclease protection assay and by Northern blotting, respectively. Results: NE treatment significantly increased IGF-1 mRNA levels in both left- and right-ventricle; however, levels of IGF-1R increased in the left- but not the right-ventricle. By contrast, NE infusion at both the lower dose and the higher dose failed to alter expression of SERCA2 mRNA. Conclusion: Our results suggest that NE treatment differentially regulates expression of IGF-1 and IGF-1R in the ventricles of rat heart and that NE appears not to affect expression of SERCA2 mRNA.

KEYWORDS Rat, ventricle; Insulin-like growth factor; Catecholamines; Ca2+-ATPase


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