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Cardiovascular Research 1997 36(1):111-117; doi:10.1016/S0008-6363(97)00145-4
© 1997 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Effects of sympathetic nerve blockade on vasoconstrictive properties of nitric oxide synthase inhibition in sheep

Michael Booke, Rene Waurick, Hugo Van Aken*, Hans-Georg Bone, Andreas Meißner, Thomas Prien and Jörg Meyer

Department of Anesthesiology and Intensive Care Medicine, University of Münster, Albert-Schweitzer-Str. 33, 48129 Münster, Germany

* Corresponding author. Tel. +49 251 837255; Fax: +49 251 88704.

Objective: Inhibition of nitric oxide synthase causes intense vasoconstriction. This effect is thought to be dependent on sympathetic nerve activity. Thus, we investigated the vasoconstrictive effects of the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) in sheep, in which a reversible sympathetic block was established by thoracic epidural anesthesia. Methods: Sheep (n = 11) were surgically prepared for chronic study. After at least 5 days of recovery, L-NAME was continuously administered and hemodynamics were monitored. This was done in sheep with and without sympathetic blockade in randomized order. Results: The vasoconstrictive effects of L-NAME were similar in sheep with and without sympathetic blockade. Conclusion: The obtained results suggest that the vasoconstrictive properties of nitric oxide synthase inhibitors are independent of sympathetic tone.

KEYWORDS Nitric oxide synthase inhibition; Epidural anesthesia; Sympathetic nerve activity; Hemodynamics; Sheep


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