Skip Navigation

Cardiovascular Research 1997 35(1):120-124; doi:10.1016/S0008-6363(97)00090-4
© 1997 by European Society of Cardiology
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ossei-Gerning, N
Right arrow Articles by Grant, P.J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ossei-Gerning, N
Right arrow Articles by Grant, P.J
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1997, European Society of Cardiology

Helicobacter pylori infection is related to atheroma in patients undergoing coronary angiography

N Ossei-Gerninga,*, P Moayyedib, S Smithc, D Braunholtzd, J.I Wilsone, A.T.R Axonb and P.J Granta

aUnit of Molecular Vascular Medicine, Leeds General Infirmary, Leeds LS1 3EX, UK
bCentre for Digestive Diseases, Leeds General Infirmary, Leeds LS1 3EX, UK
cDepartment of Microbiology, Leeds General Infirmary, Leeds LS1 3EX, UK
dDepartment of Epidemiology and Public Health Medicine, Leeds University, Leeds, UK
eDepartment of Cardiology, Pinderfields Hospital, Wakefield, UK

* Corresponding author. Tel.: +44 (113) 292 3472; fax: +44 (113) 242 3811.

Objectives: Helicobacter pylori infection has been related to an increased risk of ischaemic heart disease (IHD) possibly by raising plasma fibrinogen. The evidence for this association is conflicting. Furthermore, no attempt has been made to distinguish between an effect on atheroma and thrombosis. We have determined the association of H. pylori status with IHD assessed by coronary angiography. We have also evaluated the influence of H. pylori infection on haemostatic factors. Methods: Caucasian patients undergoing coronary angiography for suspected IHD were recruited. H. pylori status was determined by serology (Helico G). Plasma fibrinogen was measured by the Clauss assay. Coronary angiograms were assessed and significant atheroma defined as ≥50% stenosis. A history of myocardial infarction was ascertained by WHO criteria. Results: 292 patients were recruited (median age 59, 95 female); 204 (70%) patients had IHD and 185 (64%) of all patients were H. pylori-positive; 68% patients with IHD were H. pylori-positive compared with 50% without IHD (P = 0.003). When adjusted for other risk factors by logistic regression, H. pylori remained significantly associated with IHD (odds ratio=2.4, 95%CI=1.2–5.1, P = 0.02). H. pylori status was not related to a history of myocardial infarction. Circulating levels of PAI-1, vWF, Factor VII and fibrinogen were not related to H. pylori status. Conclusion: This study suggests that infection with H. pylori is associated with coronary atheroma, but that this relationship is unlikely to be mediated through raised plasma fibrinogen.

KEYWORDS Helicobacter pylori; Coronary atheroma; Thrombosis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 ANGIOLOGYHome page
S. Abou-Raya, A. Naeem, H. A.-E. Kheir, and S. El Beltagy
Coronary Artery Disease and Periodontal Disease: Is There a Link?
Angiology, March 1, 2002; 53(2): 141 - 148.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.