© 1997 by European Society of Cardiology
Copyright © 1997, European Society of Cardiology
Role of interventricular dispersion of repolarization in acquired torsade-de-pointes arrhythmias: reversal by magnesium
Department of Cardiology, Cardiovascular Research Institute Maastricht, University of Limburg, Maastricht, P.O. Box 5800, 6202 AZ Maastricht, Netherlands
* Corresponding author. Tel.: +31 (43) 3875095; fax: +31 (43) 3875104.
Objective: The mechanism of acquired torsade-de-pointes arrhythmias (TdP) is not clear but is suggested to be based on several parameters including early afterdepolarizations (EADs) and/or dispersion of repolarization (
APD). In our animal model of TdP (anaesthetized dogs with chronic AV block), we assessed the relevance of interventricular dispersion for the initiation of TdP. Methods: In 24 experiments, multiple endocardial monophasic action potential (MAP) recordings were made at baseline, after d-sotalol (2 mg/kg), and after MgSO4 (100 mg/kg, n=11) to measure regional differences in action potential duration (APD). Rate-dependent behavior of the interventricular APD (APD of left minus right ventricle) and intraventricular dispersion was studied under the different circumstances. Results: Dogs with induction of TdP by d-sotalol and pacing (11/20=55%) had longer cycle lengths of idioventricular rhythm, longer QT-durations, increased presence of EADs (14/22 vs 5/18 MAPs, P<0.05) and increased interventricular APD (135±55 vs 60±40 ms, P<0.05) compared with non-inducible dogs. There were no differences in intraventricular dispersion. MgSO4 diminished APD (110±45 to 55±60 ms, P<0.05) and prevented TdP (4/4). In contrast to intraventricular dispersion, interventricular APD is clearly bradycardia-dependent. Conclusions: Next to bradycardia, prolonged repolarization, and EADs, we propose that APD should be added to the relevant factors for the initiation of TdP. Interventricular dispersion is much larger than intraventricular dispersion and demonstrates a very strong bradycardia dependence.
KEYWORDS Arrhythmias; Monophasic action potential; Early afterdepolarization; Dog, anesthetized; Magnesium
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