Skip Navigation

Cardiovascular Research 1997 33(3):671-676; doi:10.1016/S0008-6363(96)00250-7
© 1997 by European Society of Cardiology
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow E-letters: Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when E-letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Xie, Z.
Right arrow Articles by Koyama, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Xie, Z.
Right arrow Articles by Koyama, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1997, European Society of Cardiology

The capillarity of left ventricular tissue of rats subjected to coronary artery occlusion

Zhonglin Xie, Ming Gao, Sanjay Batra1 and Tomiyasu Koyama*

Research Institute for Electronic Science, Hokkaido University, Sapporo 060, Japan

Objective: The effects of chronic coronary occlusion on the capillarity of left ventricular tissue in rat heart. Methods: The heart was exposed through a left-sided thoracotomy in ethylether-anesthetized and ventilated rats. The left coronary artery was occluded with a thin suture and the thorax was closed. Thirty days after the surgery the heart was removed and cross-sections were made for morphometric analyses. Results: The cross-sectional area of cardiomyocytes increased markedly in the subepi- and subendocardia with a concomitant increase in the capillary to myocyte ratio. The total capillary density increased in the non-ischemic zone. The balance between the increase in capillary density and myocyte hypertrophy was assessed from the capillary domain area (CDA). CDAs were significantly smaller for the venular capillary portion in the subendocardial non-ischemic zone. However, CDAs in the transition zone around the necrosis were significantly increased in the venular capillary portion in the subendocardium and in all capillary portions in the subepicardium compared with those in the non-ischemic zone. Immunohistological staining for basic fibroblast growth factor (bFGF) revealed punctate bFGF distribution in both the non-ischemic and transition zones of ventricular tissues 30 days after occlusion, suggesting a persistent stimulation for capillary angiogenesis. Conclusion: The remodelling of the capillary bed is not uniform throughout the cardiac tissue in coronary-occluded rat hearts. CDAs decreased in the non-ischemic zone but increased in the transition zone. The rate of capillary angiogenesis failed to parallel the development of hypertrophy in the transition zone over 30 days, as could be seen from the significant reduction in the percentage of venular capillary portions.

KEYWORDS Coronary occlusion; Hypertrophy; Arterioles; Venules; Capillary density; Rat, heart

1 JSPS Scientist.

* Corresponding author. Tel./Fax +81 11 757-1692.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 CirculationHome page
K. N. Le, C.-W. Hwang, A. R. Tzafriri, M. A. Lovich, A. Hayward, and E. R. Edelman
Vascular Regeneration by Local Growth Factor Release Is Self-Limited by Microvascular Clearance
Circulation, June 9, 2009; 119(22): 2928 - 2935.
[Abstract] [Full Text] [PDF]

Home page
 J CARDIOVASC PHARMACOL THERHome page
D. Brasil, R. M. Temsah, K. Kumar, H. Kumamoto, N. Takeda, and N. S. Dhalla
Blockade of 5-HT2A Receptors by Sarpogrelate Protects the Heart Against Myocardial Infarction in Rats
Journal of Cardiovascular Pharmacology and Therapeutics, March 1, 2002; 7(1): 53 - 59.
[Abstract] [PDF]

Home page
 CirculationHome page
C. Waller, K.-H. Hiller, E. Kahler, K. Hu, M. Nahrendorf, S. Voll, A. Haase, G. Ertl, and W. R. Bauer
Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart
Circulation, March 20, 2001; 103(11): 1564 - 1569.
[Abstract] [Full Text] [PDF]

Home page
 ANGIOLOGYHome page
T. Hasegawa, A. Kimura, M. Miyataka, M. Inagaki, and K. Ishikawa
Basic Fibroblast Growth Factor Increases Regional Myocardial Blood Flow and Salvages Myocardium in the Infarct Border Zone in a Rabbit Model of Acute Myocardial Infarction
Angiology, June 1, 1999; 50(6): 487 - 495.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
H. Kumamoto, H. Okamoto, M. Watanabe, H. Onozuka, K. Yoneya, I. Nakagawa, S. Chiba, S. Watanabe, T. Mikami, K. Abe, et al.
Beneficial effect of myocardial angiogenesis on cardiac remodeling process by amlodipine and MCI-154
Am J Physiol Heart Circ Physiol, April 1, 1999; 276(4): H1117 - H1123.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.