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Cardiovascular Research 1997 33(3):650-654; doi:10.1016/S0008-6363(97)00008-4
© 1997 by European Society of Cardiology
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Copyright © 1997, European Society of Cardiology

Prevention by selenium supplementation of cyclosporin-A-induced vascular toxicity

Guy Berkenboom*,a, Dmitri Brékinea, Zhen Y. Fanga, Jean Nèveb and Jeanine Fontaineb

aCardiology Department, Erasmus Hospital, Route de Lennik 808, 1070 Brussels, Belgium
bPharmacology Department, Institute of Pharmacy, Free University of Brussels, Brussels, Belgium

Objective: The aim was to determine whether selenium supplementation, an important component of glutathione peroxidase, might attenuate cyclosporin (Cx)-induced vascular toxicity. Methods: Four groups of rats were treated in parallel: the first group was supplemented with selenium (sodium selenite, 0.5 mg · kg–1) orally (p.o.) for 5 weeks and the same dose of selenium plus Cx 20 mg · kg–1 (i.m.) during the 6th week; group 2 received Cx only (20 mg · kg–1 i.m. for 1 week); group 3 was supplemented with selenium (0.5 mg · kg–1 p.o., for 6 weeks) and group 4 served as control. Thoracic aortas isolated from these various groups were studied in organ baths. Results: In comparison with the control group, selenium supplementation did not modify acetylcholine (Ach)- and nitroprusside-induced relaxations. In group 2, endothelium-dependent relaxations (Ach) were markedly impaired and endothelium-independent relaxations (nitroprusside) were shifted to the right; with selenium supplementation (group 1), the responses to Ach were partially restored whereas the rightward shift of the concentration-response curves to nitroprusside persisted. Incubation with superoxide dismutase (SOD, 150 IU · ml–1) or selenium (1 µg · ml–1) (but not with selenium plus an inhibitor of the glutathione redox cycle) improved the relaxations to Ach in group 2. Conclusions: The vascular toxicity of Cx seems related to generation of oxygen-derived radicals promoting EDRF destruction and is attenuated by selenium supplementation.

KEYWORDS Cyclosporin; EDRF; Rat, aorta; Selenium

* Corresponding author. Tel. +32 2 5553907; Fax +32 2 5554609.


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