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Cardiovascular Research 1992 26(2):109-114; doi:10.1093/cvr/26.2.109
© 1992 by European Society of Cardiology
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Copyright © 1992, European Society of Cardiology

Left ventricular function and the relationship between left atrial pressure and peak early diastolic filling velocity in dog

Satoshi Nakatani, Shintaro Beppu, Kunio Miyatake and Yasuharu Nimura

National Cardiovascular Centre, Research Institute, 5-7-1 Fujishiro-dai, Suita, Osaka 565, Japan: S Nakatani, S Beppu, K Miyatake, Y Nimura.

Correspondence to Dr Nakatani.

Objective: The aim was to clarify the roles of left atrial pressure and ventricular function in the determination of early diastolic filling. Methods: Various grades of ventricular dysfunction were made in 12 mongrel dogs by coronary microembolisation under pentobarbitone anaesthesia. Left atrial pressure was altered by volume loading. Peak early diastolic filling velocity was measured using pulsed Doppler echocardiography. Ventricular fractional shortening was measured using M mode echocardiography. Results: Peak early filling velocity increased as left atrial pressure increased. There was a direct relationship between mean left atrial pressure and the velocity before and after induction of ventricular dysfunction. The slope of the regression line between mean left atrial pressure and peak early filling velocity decreased as the grade of the dysfunction increased. There was a significant correlation between the slope of the regression line and mean left ventricular fractional shortening (r = 0.65, n=31, p < 0.01). Conclusions: Early diastolic filling was affected by both left atrial pressure and left ventricular function. These facts are useful in interpreting the various transmitral flow patterns observed clinically.

KEYWORDS diastole; Doppler echocardiography; preload; cardiac; function


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