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Cardiovascular Research 1983 17(2):88-95; doi:10.1093/cvr/17.2.88
© 1983 by European Society of Cardiology
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Copyright © 1983, European Society of Cardiology

Effects of adrenaline on a compartment of slowly-exchangeable calcium in the perfused rat heart

SUZANNE V LAMONT and GREGORY J BARRITT*

From the Department of Clinical Biochemistry, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, South Australia

* Address for reprint requests: Dr G J Barritt, Department of Clinical Biochemistry, Flinders University School of Medicine, Flinders Medical Centre, Bedford Park, South Australia, 5042.

The effects of adrenaline on kinetically-distinct compartments of exchangeable calcium in the spontaneously-beating perfused rat heart were investigated under steady-state conditions using a 45Ca2+ outflow technique together with a nonlinear least-squares curve fitting procedure and 51Cr-EDTA to monitor the loss of freely-diffusible Ca2+ from the extracellular space. In addition to Ca2+ distributed in the vascular (compartment 1) and interstitial (compartment 2) spaces, the minimum number of kinetically-distinct compartments of cellular exchangeable Ca2+ (which include Ca2+ bound to extracellular sites on the sarcolemma) required to fit the data (compartments 3,4 and 5) was three. A system in which cellular compartment 3 is linked to the vascular space and compartments 4 and 5 are linked to the interstitial space was consistent with the data. For hearts perfused under control conditions, the fractional transfer rates for Ca2+ outflow from cellular compartments 3, 4 and 5 were 0.70, 0.11 and 0.017 min–1, respectively. Adrenaline increased the quantity of exchangeable Ca2+ in compartment 5 and decreased that present in the compartment 4. Evidence that compartment 5 includes mitochondrial exchangeable Ca2+ is discussed. It is concluded that one of the actions of adrenaline on the heart is to increase the quantity of exchangeable Ca2+ in the mitochondria.

KEYWORDS Calcium; physiology; heart; physiology; kinetics; adrenaline


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