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Cardiovascular Research 1967 1(1):2-8; doi:10.1093/cvr/1.1.2
© 1967 by European Society of Cardiology
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Copyright © 1967, European Society of Cardiology

Effects of Increasing Frequency of Contraction on the Force Velocity Relation of Left Ventricle

James W. Covell, John Ross, Jr., Roger Taylor, Edmund H. Sonnenblick and Eugene Braunwald

From the Cardiology Branch, National Heart Institute, Bethesda, Maryland, U.S.A.

Authors' Synopsis: The effects of increasing the frequency of contraction on the mechanics of left ventricular contraction were studied in nine canine preparations in which filling pressure was controlled. Increasing the contraction rate produced significant increases in maximum contractile element velocity and maximum wall tension in isovolumic beats, and this augmentation of contraction was evident despite an abbreviation of systole.


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