Skip Navigation

Cardiovascular Research 1999 44(2):449; doi:10.1016/S0008-6363(99)00246-1
© 1999 by European Society of Cardiology
This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gardiner, S.M
Right arrow Articles by Bennett, T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gardiner, S.M
Right arrow Articles by Bennett, T
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Copyright © 1999, European Society of Cardiology

Comment on "Interactions between endothelin-1 and the renin-angiotensin-aldosterone system"

S.M Gardiner* and T Bennett

School of Biomedical Sciences, Medical School, University of Nottingham, Nottingham NG7 2UH, UK

* Corresponding author. Tel.: +44-115-970-9484; fax: +44-115-9709-259

Received 27 July 1999; accepted 5 August 1999

In a recent review, Rossi et al. [1] considered interactions between endothelin-1 and the renin angioten-sinaldosterone systems, and cited our work [2,3] on the super-additive vasodilator and hypotensive effects of the non-selective endothelin receptor antagonist, SB 209670, and losartan in hypertensive male, heterozygous, transgenic ((mRen-2)27) rats. In these animals we observed clear effects of SB 209670 alone, and discussed reasons why endothelin should be involved in what was, nominally, a model of hypertension created by manipulation of the renin-angiotensin system. Unfortunately, Rossi et al. [1], while citing our work, seem not to have understood that we investigated male, heterozygous transgenic rats and also found an effect of endothelin receptor antagonism alone, because they conclude that, in this model of hypertension, endothelin does not play any major role! So, while we are grateful for the citations, we feel that the conclusions reached by Rossi et al. [1] should be more guarded, since the only published work [4] which conflicts with our findings used a different endothelin receptor antagonist and a different source of Sprague Dawley rats for the heterozygous cross (Edinburgh vs. Hannover). Perhaps, therefore, the area is still open for investigation.


   References
Top
 References
 

  1. Rossi G.P., Sacchetto A., Cesari M., Pessina A.C. Interactions between endothelin-1 and the renin-angiotensin-aldosterone system. Cardiovasc. Res. (1999) 43:300–307.[Abstract/Free Full Text]
  2. Gardiner S.M., March J.E., Kemp P.A., Mullins J.J., Bennett T. Haemodynamic effects of losartan and the endothelin antagonist, SB 209670, in conscious, transgenic (mRen-27), hypertensive rats. Brit. J. Pharmacol. (1995) 116:2237–2244.[ISI][Medline]
  3. Gardiner S.M., Kemp P.A., March J.E., Bennett T. Enhanced involvement of endothelin in the haemodynamic sequelae of endotoxaemia in conscious, hypertensive, transgenic ((mRen-2)27) rats. Brit. J. Pharmacol. (1998) 123:1403–1408.[CrossRef][ISI][Medline]
  4. Whitworth E., Veniant M., Firth J., Cumming A., Mullins J. Endothelin in the kidney in malignant phase hypertension. Hypertension. (1995) 26:925–931.[Abstract/Free Full Text]

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?



This Article
Right arrow Extract Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Gardiner, S.M
Right arrow Articles by Bennett, T
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gardiner, S.M
Right arrow Articles by Bennett, T
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?