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Cardiovascular Research 1999 43(3):639-649; doi:10.1016/S0008-6363(99)00085-1
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Copyright © 1999, European Society of Cardiology

Role of nitric oxide in the neural control of cardiovascular function

Johannes Zanzinger*

I. Physiologisches Institut, Universität Heidelberg, Heidelberg, Germany

* Present address: Animal Health Discovery Department, Pfizer Central Research, Ramsgate Road, Sandwich, Kent CT13 9NJ, UK. Tel.: +44-1304-646697; fax: +44-1304-656595 zanzingerj{at}aol.com

Received 11 December 1998; accepted 10 February 1999


   Abstract
Top
 Abstract
1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
 5 Human studies
 6 Pathophysiological...
 7 Conclusions
 References
 
The discovery in 1990 that nitric oxide (NO) acts as a neuromodulator within the central and peripheral nervous system triggered intensive research which considerably extended our understanding how this factor regulates cardiovascular functions. In addition to its direct effects on blood vessels NO has additional targets at all levels of the neural control of circulation. When not scavenged by hemoglobin, NO is relatively stable and diffuses over large distances (>500 µm) so that one NO-producing cell can influence several thousends of adjacent cells in vivo. In different brain regions, NO and its metabolites have excitatory as well as inhibitory effects. The modulation of autonomic functions by these factors is therefore highly complex and often variable between the different levels from the brain to postganglionic nerve endings. This review is focused on the available evidence derived from animal studies and will summarize the current discussion about (i) the modulation of the generation of sympathetic and parasympathetic activities within the brain stem by NO; (ii) the actions of NO on cardiovascular reflexes and (iii) the role of NO as a modulator of autonomic functions within the target organs. Finally, the available evidence from human studies and some pathophysiological implications of altered NO-mediated modulation of the neural control of circulation will be discussed.


   1 Introduction
Top
 Abstract
 1 Introduction
2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
 5 Human studies
 6 Pathophysiological...
 7 Conclusions
 References
 
The neural control of circulation represents a complex network of regulatory influences on heart and blood vessels provided by the activity of postganglionic sympathetic, parasympathetic and so-called non-adrenergic non-cholinergic (NANC) nerves, and by circulating catecholamines from the adrenal gland. Since the discovery that nitric oxide (NO) is not only a regulator of smooth muscle tone but also a neuromodulator within the central and peripheral nervous system [1,2] it is clear that the cardiovascular actions of this molecule are probably not confined to its direct effects on blood vessels and blood cells but comprise, in addition, effects on all neural substrates that contribute to the generation of the activity of autonomic nerves in the central and peripheral nervous system. In the absence of hemoglobin, its major sink in vivo [3], NO is a relatively stable molecule that diffuses over relatively large distances (>500 µm) in brain tissue [4,5], and S-Nitrosothiols generated in reactions of NO with thiol-containing peptides or proteins such as gluthathion or albumin can store NO-equivalents and transport them even with the blood stream [6,7]. This means that, in principle, almost every tissue is continuously influenced by changing concentrations of NO and its metabolites. Effects of NO are prominent in brain regions that control sympathetic and vagal activities and, in addition, NO modulates the transmission of autonomic neural activity to target organs by actions within the spinal cord, ganglia and neuromuscular junctions. The resultant complex interaction of NO with autonomic functions implies that pathophysiological changes in the synthesis and metabolism of NO may have direct consequences for the neural control of circulation. Cardiovascular diseases in which altered neuronal effects of NO are probably important include essential hypertension, atherosclerosis, heart failure, septic shock and even diabetes mellitus. This review aims to summarize recent findings on the physiology of NO-actions within the auntonomic nervous system and to give a brief overview on the role of NO as a pathogenic factor in the development of neurohumoral dysfunction in cardiovascular diseases.


   2 Synthesis and cellular functions of NO within the brain
Top
 Abstract
 1 Introduction
 2 Synthesis and cellular...
3 Neural control of...
 4 Neural control of...
 5 Human studies
 6 Pathophysiological...
 7 Conclusions
 References
 
The activity of preganglionic autonomic nerves is integrated by specialized neuronal cell populations that are located in the lower brain stem in close contact to each other and with the regions involved in the control of respiration [8–10]. The functional organization of the sympathetic and parasympathetic chains and the potential targets for NO are shown in Fig. 1. When neuronal NOS-density is taken as the indicator, it appears that endogenous NO-formation within the brain stem is relatively low when compared to other regions such as the hippocampus, the cortex or the cerebellum [11–14] but there are considerable differences in the NOS-density within the brain stem between species [15]. This is important because the actions of NO in neuronal cells are largely dependent on the effective concentration over time. The complexity and variability of NO-actions on the cellular level can be deduced from the variety of different biochemical reactions triggered by this molecule. Some of the most important ones are listed in Table 1. NO can produce both excitatory as well as inhibitory effects in neurons so that whether NO acts as an excitatory or inhibitory neuromodulator in a specific brain region may depend not only on the neuronal cell type but directly and importantly also on the spatio-temporal relationship of the concentrations of NO and its metabolites within tissues.


Figure 1
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  		Fig. 1 Functional organization of the neural control of circulation. Abbreviations: RVLM: rostral ventrolateral medulla; AMB: Nucleus ambiguus; DMV: Dorsal motor nucleus of the vagus; IML: Intermediolateral cell column; SPG: Sympathetic ganglion.

 

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  		Table 1 Intracellular targets and mechanisms of action of NO in neuronal cellsa

 
2.1 Central regulation of sympathetic activity
In 1991 Shapoval et al. [16] published the first study that proposed a direct effect of NO within the RVLM on sympathetic nerve activity (SNA). Microinjections of the NOS-inhibitor L-NAME into this area increased and the NO-donor sodium nitroprusside inhibited renal SNA in cats. Most subsequent studies [17–21] supported the concept that endogenously released NO has inhibitory effects in RVLM-neurons. The underlying mechanisms probably consist of an attenuation of glutamatergic excitation [22] in presympathetic neurons within the RVLM and, in addition, a reduction of similarly excitatory effects of angiotensin II in that region [23]. The predominant stimulus for NO-release is probably the activation of the calcium dependent neuronal NO-synthase via calcium influx through NMDA glutamate receptors [24,25]. Endothelial NO-sources seem to be less important [22].

However, in two studies the opposite (i.e. sympathoexcitation) was observed when NO-donors were injected into the RVLM at concentrations in the upper millimolar range [26,27]. Furthermore, there are no significant changes in baseline sympathetic nerve activity (SNA) when neuronal NOS is specifically blocked either systemically or within the whole brain stem or when baroreceptor denervated animals are studied in which BP-changes have no direct influence on SNA [22,28]. The most likely explanation for this is that NO produced by, or administered to, the lower brain stem similarly affects the caudal ventrolateral medulla (CVLM) that provides an GABA-ergic inhibitory projection to the RVLM [29,30]. Thereby, the actions of NO on both regions could cancel out each other. However, it is important to note that systemic or organ-wide blockade of NO-synthesis represents a rather artificial experimentally induced situation and that NO-synthesis and actions in both regions are probably seperately regulated in vivo. The complexity of NO-action becomes further apparent in the nucleus of the solitary tract (NTS). Increases in NO-concentrations in that region consistently produces sympathoinhibition [31–34] although it is not only a relay for the sympathoinhibitory baroreceptor-reflexes but also for a number of sympathoexcitatory reflexes such as the chemoreflexes [35]. Most studies proposed that in the NTS, in contrast to the RVLM, the cellular effect of NO may be primarily excitatory through retrograde enhancement of presynaptic glutamate release as initially described for hippocampal neurons [36]. Thus, the available evidence suggests that NO can have both inhibitory as well as excitatory effects even in relatively nearby regions and this phenomenon has been similarly observed within the spinal cord [37]. Previous observations showing that glutamate receptors antagonists cause significant hypotension in most models [38–40] may favour a predominance of the inhibitory effects of NO. However, these compounds act primarily by prevention of direct glutamate effects (depolarization) and only secondarily through reduction of glutamate evoked NO-release. Nevertheless, glutamate antagonists probably reduce NO-release in general thereby preventing potentially both the inhibitory and the excitatory actions of NO in different brain regions.

On the basis of the findings described above it is not surprising that the numerous studies in which sympathetic activity was measured following systemic inhibition of all NOS-isoforms in whole animals or humans yielded completely heterogenous results. Some authors reported increases [41–43], others found decreases [44–47] or no changes in SNA [48–50]. In a recent study on rats [51], even an increase in renal and a decrease in lumbar SNA was observed following systemic NOS-inhibition. The explanation for these confusing results must not only be sought in the diversity of NO-actions but also in the fact that the generation of sympathetic activity within the RVLM is a result of the similarly complex interaction many excitatory inputs that come from higher brain regions and bodily reflexes (Fig. 1) and from inhibitory inputs provided by baroreceptor afferents. One simple reason for divergent findings in intact animals is therefore the fact is that blood pressure increases produced by systemic NOS-inhibition cause a baroreflex mediated inhibition of SNA [52,53], an effects which most important in acute experiments but much less in chronic studies because baroreceptor reflexes reset to altered BP-levels within relatively short periods [54–57].

Taken together it appears that at least under physiological conditions, endogenously released NO in effect reduces overall sympathetic excitability within the brain stem and, in addition, possibly through actions in higher brain regions such as the hypothalamus [58–60] or the limbic system.

2.2 Parasympathetic activity
A major cardiovascular effect of systemic NOS-inhibition is long-lasting bradycardia [61–63] caused by either direct central effects or by enhancement of the baroreflex-mediated activation of vagal tone. Several groups have suggested that centrally acting NO may modulate preganglionic parasympathethetic neurons within the nucleus ambiguus (AMB) and dorsal vagal motor nucleus (DMV) [64–66] an effect that may not only affect heart rate but significantly alter gastrointestinal functions as well. Furthermore, in the NTS, NO appears to excite neurons with connections to the DMV and AMB [67]. Experiments on conscious rabbits [50,68], however, show that NOS-inhibition increases baroreflex mediated bradycardia. Therefore, it seems that the modulation of central parasympathetic activity may be, in principle, similarly organized as described for the sympathetic chain i.e. the net effect of NO is an attenuation of the overall excitability resulting in a reduction of the efferent outflow.

2.3 Cardiovascular reflexes
Most studies concerned with cardiovascular reflexes such as the chemoreceptor reflex [69–74], the muscle metabo- or exercise pressor reflex [64,75,76] and somatovisceral reflexes [17,22,77] equivocally reported direct or indirect inhibitory effects of NO on the sympathoexcitation produced by these reflexes. In addition to inhibitory actions of NO at the level of the peripheral receptors, there may be modulation of reflex transmission within the brain i.e. in the NTS and RVLM. Parasympathetic reflex components are similarly affected. The increase in parasympathetic tone (bradycardia) produced by activation of cardiopulmonary receptors for example (Bezold–Jarisch reflex), may be also reduced by central actions of NO primarily within the NTS and the nucleus ambiguus [78].

In contrast to the overall inhibitory modulation by NO of excitatory reflex inputs to the brain stem regions that regulate autonomic activities, is much less clear how NO modulates the sympathoinhibitory baroreceptor reflex in vivo. Baroreceptors have their first synapses in the NTS and are then further relayed to the caudal ventrolateral medulla (CVLM) which provides an GABA-ergic inhibition of the RVLM [52,53,79]. Activation of baroreceptor afferents by increases in blood pressure and/or pulse amplitudes thus reduces sympathetic outflow from the RVLM. Studies concerned with the role of NO in the sympathetic part of the baroreceptor reflex came up with rather heterogenous results. Attenuation [21,80] and enhancement [81] of baroreceptor reflex fuctions as well as indifferent responses [46,49] to systemic variation of endogenous or exogenous NO-levels have been reported. Other studies that were more directly focused on the neurophysiological mechanisms underlying modulation of the reflex pathway similarly yielded more or less contradictory results. Matsuda and Coworkers [82] found inhibitory effects of NO on arterial baroreceptors in the carotid sinus which were later explained by direct inhibitory actions on sodium channels [83]. However, the physiological relevance of these effects remain to be determined since in experiments on cats [84] using a modified blind sack preparation of the carotid sinus that preserved pulsatile pressure stimuli, we could not find significant modulation of baroreceptor activity by NO. Furthermore, microinjections of NO or NOS-inhibitors into the central relays of the baroreflex (i.e. NTS, CVLM, RVLM) failed to alter baroreflex responses produced by electrical stimulation of the carotidsinus nerve [85]. Although at present a definitive conclusion cannot yet be drawn and despite the fact that there may be species differences as well, it seems that arterial baroreceptor reflexes may be much less affected by NO than the sympathoexcitatory pathways described above.


   3 Neural control of the heart
Top
 Abstract
 1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
4 Neural control of...
 5 Human studies
 6 Pathophysiological...
 7 Conclusions
 References
 
Besides its actions on the activity of preganglionic autonomic nerves, NO directly influences the intrinsic cardiac nervous system which consists of efferent sympathetic and parasympathetic postganglionic neurons, chemo- and mechanosensitive afferent neurons and local circuit neurons [86,87]. Between 30 and 40% of these neurons are NOS-positive in dogs [88]. Endogenous as well as exogenous NO excites these neurons leading to moderate positively inotropic and chronotropic responses as a net effect in vivo [88,89]. Furthermore, NO has additional effects at the level of parasympathetic postganglionic nerve endings that may be particularly important within the heart. Acetylcholine released by these fibers causes NO-release from the coronary endothelium which in turn cause vasodilation [90,91] and cholinergic inhibition of L-type calcium channels [92] in pacemaker cells. Cardioprotective reflexes such as the Bezold–Jarisch reflex (i.e. the increase in parasympathetic activity upon stimulation of cardiac chemo- and mechanoreceptors) may be also locally enhanced via this mechanism [93,94]. Finally, NO has been shown to inhibit the release of noradrenaline from sympathetic nerves within the heart [95,96]. This may not only attenuate sympathetically mediated coronary vasoconstriction but particularly at higher concentrations, reduce the inotropic as well as the arryhthmogenic effects of sympathetic stimuli [97,98]. Interestingly, periods of ischemia and reperfusion are associated with enhanced release of NO [99] and the effects of myocardial stunning are significantly aggravated following NOS-inhibition in dogs [100]. Thus, almost all current studies point to an overall cardioprotective role of the neuronal effects of constitutively released NO within the heart. However, whether high concentrations of NO produced for example by inducible NOS during sepsis or chronically in heart failure, still have beneficial effects or may even be damaging, it is much less clear [101].


   4 Neural control of blood vessels
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 Abstract
 1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
5 Human studies
 6 Pathophysiological...
 7 Conclusions
 References
 
4.1 General mechanisms
The vasodilating properties of NO are brought about by a reduction of vascular smooth muscle tone which is generated by either adrenergic, myogenic or humoral influences. Each constrictor mechanism contributes to a different extent to the regulation of organ blood flow but in general, the constrictor tone of blood vessels is a result of a combination of all. A number of studies both in vitro [102–106] and in vivo [28,107–110] have shown that NO very effectively counteracts sympathetic vasoconstrictor mechanisms. This interaction consists of at least two mechanisms: (1) The inhibition of NA-release from postganglionic nerve endings by NO and (2) intracellular antagonism of the noradrenergic signal transduction pathway that may be more effective than the inhibition of other vasoconstrictor mechanisms. Partially, the specificity is also caused by the widespread nitroxidergic innervation of the vasculature [111–114] which causes abluminal NO-release directly to the sympathetic varicosities.

The most important role of the interaction of NO with sympathetic vasomotor activity is probably to enable adequate perfusion of metabolically active organs upon general sympathetic activation during excercise or stressful situations [115,116]. NO primarily released by the endothelium when shear rates increase due to enhanced blood flow reduce both the release and the constrictor effects of noradrenaline thereby supporting flow dependent dilation. In rats, it has been shown that some postganglionic sympathetic nerves, in addition, contain preformed nitrosyl factors that are co-released upon increases in SNA contributing to the vasodilation in exercising organs in the presence of elevated {alpha}-adrenergic tone [117]. These mechanisms may be particularly important in feeding arteries and arterioles that are not under direct metabolic vasodilator influence.

The relevance of the modulation of sympathetic constrictor mechanisms by NO has been questioned by some authors recently [46,47,118] because the vasodilator effects of NO were preserved in animal models with reduced or absent sympathetic vasoconstrictor activity. However, these results were not surprising as studies on isolated vessels clearly show. NO is still an effective dilator agent when the constrictor tone of blood vessels is not generated by SNA but by myogenic mechanisms or constrictor agonists. However, in the living organism sympathetic mechanisms play a predominant role in the regulation of organ blood flow through the precise adjustment of vascular resistance in the feeding vessels. And when vascular sympathetic activity is on a normal level in vivo, NO almost exclusively reduces sympathetic constriction in most organs [28]. The importance of the modulation of sympathetic vasoconstriction by NO is therefore directly dependent on the importance of sympathetic control of circulation itself.

4.2 Vaso-neuronal coupling in the CNS
Vascular tone and blood flow within the CNS are tightly coupled to the metabolic activity of neurons within specific brain regions. Neuronally released NO diffusing to adjacent blood vessels mediates, probably together with adenosine [119], activity-dependent vasodilation and local increases in cerebral blood flow [120]. Activation of neuronal NOS by the rise of intracellular calcium following binding of glutamate to NMDA-receptors may underly this phenomenon [25,121–123]. Furthermore, the above described release of NO from parasympathetic perivascular NANC-nerves may be also involved in the specific feed foward regulation of blood flow to active brain regions [114,124–126]. Finally, it has been suggested that NO may affect vaso-neuronal coupling by mediating the hypercapnic rise in cerebral blood flow [127], but subsequent studies did not support this hypothesis [128–130]. However, NO has probably a permissive role in the vasodilation caused by CO2 [131] and this contribution of NO to basal vascular tone may influence other vasomotor mechanisms as well [132].

4.3 Neurogenic vasodilation in genital organs
The role of NO as a parasympathetic (NANC) transmitter is most important in the regulation of male sexual functions. In 1990 Ignarro and colleagues demonstrated the essential role of NO and cGMP as mediators of corpus cavernosum smooth muscle relaxation and thus erectile function [133]. Subsequently, it was shown that neuronal (parasympathetic) rather than endothelial sources account for the selective release of NO for erection [134–137] and that in females, the increase in blood flow through genital organs during sexual arousal may be similarly regulated [138,139]. How important this function of NO really is for many poeple may be gathered from the publicity that VIAGRA® (sildenafil, an inhibitor of phosphodiesterase V) received when it was launched worldwide as a drug for humans in 1998. This compound inhibits the breakdown of cGMP after NO-mediated activation of guanylate cyclase evoked by parasympathetic nerves in the genital tract during sexual stimulation [140]. A discussion of the variety of other functions of NO in the male and female reproductive systems has been subject of a recent review [141].


   5 Human studies
Top
 Abstract
 1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
 5 Human studies
6 Pathophysiological...
 7 Conclusions
 References
 
Due to the methodological and ethical limitations of studies on volunteers and patients, only few studies on humans addressed the effects of NO on the neural control of circulation. These studies largely supported the evidence derived from animal experiments. NO-synthases have been detected in the human brain stem including the ventrolateral medulla [142,143] and in brain regions such as the hypothalamus which provide major synaptic inputs to the RVLM [144]. Nitroxidergic innervation of blood vessels seems to play an important role in the regulation of organ blood flow in humans particularly at ateriovenous anastomoses [145], in the brain [146], genital organs (see above) [147,148], and, at least to some extent, even in skeletal muscles [149]. Furthermore, the central role of NO (derived from either the endothelium or perivascular nerves) as a functional antagonist of the sympathetic vasoconstrictor tone has been repeatedly confirmed in studies on humans [150–152]. Due to the inevitable experimental restrictions, only very limited evidence exists on the role of NO in the central regulation of sympathetic activity in humans. Baseline sympathetic activity in humans decreases in response to systemic NOS-inhibition as a result of baroreflex-mediated inhibition of sympathetic activity when blood pressure increases due to the removal of dilatory effects of vascular NO [45,46]. This is in accordance to the findings in animals. However, to what extent the inhibitory modulation of sympathetic excitability by NO may play a role in humans, could not be determined by these studies and remains to be elucidated (see also 2.1, 4.1). Nevertheless, some of the pathophysiological findings described below suggest that NO may be a relevant ‘dampening factor’ in the central control of sympathetic functions in health and disease in humans as well.


   6 Pathophysiological implications
Top
 Abstract
 1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
 5 Human studies
 6 Pathophysiological...
7 Conclusions
 References
 
The discovery of various transport and storage forms of NO and its metabolites [6,153,154] made clear that the site of production and the sites of action of NO within the body can differ significantly when the absolute amount of produced NO is high. The most studied example of acutely increased NO-production with cardiovascular consequences is septic shock. Excess NO-release largely accounts for the failure of heart and blood vessels to respond to sympathetic activation or infusion of {alpha}-adrenergic agonists in this situation [155–159]. The hopes that NOS-inhibition would improve the clinical outcome of septic patients, however, have not been satified so far, possibly because hemodynamic stabilization is achieved by the price of impaired immune responses which need such high NO-concentrations to be effective.

Chronic inflammatory processes which do occur for example in atherosclerosis, heart failure, rheumatic diseases and subclinical infections do not cause hypotension or shock but may cause deleterious alterations of the NO-biochemistry in vivo. The key event on the cellular level is enhanced production of superoxide and its reaction with NO leading to oxidative stress both directly and through the generation of peroxynitrite. The complex events and biochemical and cellular consequences associated with NO-related oxidative stress have been addressed by several reviews recently [3,160,161]. In neurons oxidative stress has primarily excitatory and/or damaging effects [162]. Therefore, although the causal relationships and the cellular mechanisms remain to be elucidated, it is tempting to speculate that the reduction of NOS-activity within the lower brainstem and the increase in sympathetic outflow that occurs both in heart failure [58] and in response to long-term exposure to enhanced NO-levels (nitrate tolerance) [163] may be functional consequences of oxidative stress within the brain.

Another factor that may affect the balance between NO and the autonomic cardiovascular control is angiotensin II (AII). It is known that AII enhances sympathetic activity and vice versa (i.e. sympathetic activity increases AII-formation) [164–168]. In a study on conscious rabbits [23], for example, central sympathoinhibitory actions of NO were only significant when AII contributed to the excitation of the RVLM and the increase in sympathetic activity during heart failure may be, at least partly, caused by activation of a local renin–angiotensin system and concomitantly reduced NO-release within the brain stem [58,169,170]. Since AII, in addition, may enhance superoxide production and reduce constitutive NO-synthesis [171], a mutual reinforcement of the pathophysiological effects of oxidative stress and AII seems likely.

Altered constitutive neuronal NO-release may also contribute to the development of essential hypertension. In spontanously hypertensive rats (SHR) neuronal NO-synthesis is different from that of control strains (WKY) both in hypothalamus and brainstem regions [172,173] as well as in preganglionic sympathetic neurons in the spinal cord [174]. This may be one explanation for the apparantly paradoxical finding that hypertensive rats have impaired endothelial dependent vasodilator responses despite increased endothelial NOS-activity [175,176] an effect that was similarly observed in patients [177]. There are some hints that the key events in the NO-related pathogenesis of essential and renal hypertension may be, similarly, increased levels of AII and NO-related oxidative stress [172,178,179] but this has to be proved in detail. Recent observations showing that even endothelin-1 may have neuromodulatory effects within the brain stem [180] provide another example how closely and highly complex the interaction of vascular and neuronal factors in the pathogenesis of cardiovascular diseases may be.


   7 Conclusions
Top
 Abstract
 1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
 5 Human studies
 6 Pathophysiological...
 7 Conclusions
References
 
The intensive research during the last decade revealed and repeatedly confirmed an important modulation of the autonomic nervous system by NO. Inhibitory actions of NO on several levels from the effector organs up to the brain regions that regulate sympathetic and parasympathetic activities constitute a functional antagonism between these systems. The primary effect of NO is probably an overall reduction of the excitability of autonomic regulation rather than a reduction of basal tonic activities and a number of local feedback control mechanisms allow highly differential regulation of the neural control of circulation by NO. However, due to the almost ubiquitous presence of NO and the tremendous diversity of cellular effects of NO at different concentrations in different tissues, there are severe hindrances for therapeutic interventions in the NO-system. Despite the intensive research within this field and despite lots of efforts to develop new NO-donors (and NOS-inhibitors) by the pharmaceutical industry, no sigificant extension of the use of NO-related drugs in cardiovascular medicine has been achieved until now. The goal of pharmacological reseach in this field should be therefore the development of more (organ-)specific drugs that activate specific cellular targets of NO or prevent the deleterious effects of NO-related oxidative stress within the autonomic nervous system.

Time for primary review 24 days.


   Acknowledgements
 
The cited work by the author was supported by grants from the German Research Foundation (DFG).


   References
Top
 Abstract
 1 Introduction
 2 Synthesis and cellular...
 3 Neural control of...
 4 Neural control of...
 5 Human studies
 6 Pathophysiological...
 7 Conclusions
 References
 

  1. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature (1988) 336:385–388.[CrossRef][Medline]
  2. Bredt D.S., Hwang P.M., Snyder S.H. Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature (1990) 347:768–770.[CrossRef][Medline]
  3. Beckman J.S., Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and the ugly. Am J Physiol Cell Physiol (1996) 40:C1424–C1437.
  4. Lancaster J.R. A tutorial on the diffusibility and reactivity of free nitric oxide. Nitric Oxide: Biology and Chemistry (1997) 1:18–30.[CrossRef][Web of Science]
  5. Garthwaite J., Boulton C.L. Nitric oxide signaling in the central nervous system. Annu Rev Physiol (1995) 57:683–706.[CrossRef][Web of Science][Medline]
  6. Keaney J.F. Jr., Simon D.I., Stamler J.S., et al. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest (1993) 91:1582–1589.[Web of Science][Medline]
  7. Liu Z.G., Rudd M.A., Freedman J.E., Loscalzo J. S-transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J Pharmacol Exp Ther (1998) 284:526–534.[Abstract/Free Full Text]
  8. Dampney R.A.L. Functional organization of central pathways regulating the cardiovascular system. Physiol Rev (1994) 74:323–364.[Free Full Text]
  9. Spyer K.M. Central nervous mechanisms contributing to cardiovascular control. J Physiol (Lond) (1994) 474:1–19.[Free Full Text]
  10. Spyer K.M., St. Lambert J., Thomas T. Central nervous system control of cardiovascular function: neural mechanisms and novel modulators. Clin Exp Pharmacol Physiol (1997) 24:743–747.[Web of Science][Medline]
  11. Blottner D., Grozdanovic Z., Gossrau R. Histochemistry of nitric oxide synthase in the nervous system. Histochem J (1995) 27:785–811.[Web of Science][Medline]
  12. Kidd E.J., Michel A.D., Humphrey P.P.A. Autoradiographic distribution of [3H]L-NG-nitro-arginine binding in rat brain. Neuropharmacology (1995) 34:63–73.[CrossRef][Web of Science][Medline]
  13. Mizukawa K., Vincent S.R., McGeer P.L., McGeer E.G. Distribution of reduced-nicotinamide-adenine-dinucleotide-phosphate diaphorase-positive cells and fibers in the cat central nervous system. J Comp Neurol (1989) 279:281–311(Abst).[CrossRef][Web of Science][Medline]
  14. Vincent S.R., Kimura H. Histochemical mapping of nitric oxide synthase in the rat brain. Neuroscience (1992) 46(4):755–784.[CrossRef][Web of Science][Medline]
  15. Zanzinger J., Seller H. Species differences in the distribution of nitric oxide synthase in brain stem regions that regulate sympathetic activity. Brain Res (1997) 764:265–268.[CrossRef][Web of Science][Medline]
  16. Shapoval L.N., Sagach V.F., Pobegailo L.S. Nitric oxide influences ventrolateral medullary mechanisms of vasomotor control in the cat. Neurosci Lett (1991) 132:47–50.[CrossRef][Web of Science][Medline]
  17. Zanzinger J., Czachurski J., Seller H. Inhibition of basal and reflex-mediated sympathetic activity in the RVLM by nitric oxide. Am J Physiol (1995) 268:R958–R962.[Web of Science][Medline]
  18. Kagiyama S., Tsuchihashi T., Abe I. Fujishima M Cardiovascular effects of nitric oxide in the rostral ventrolateral medulla of rats. Brain Res (1997) 757:155–158.[CrossRef][Web of Science][Medline]
  19. Kagiyama S., Tsuchihashi T., Abe I., Fujishima M. Enhanced depressor response to nitric oxide in the rostral ventrolateral medulla of spontaneously hypertensive rats. Hypertension (1998) 31:1030–1034.[Abstract/Free Full Text]
  20. Takeda Y., Miyamori I., Yoneda T., et al. Brain nitric oxide synthase messenger RNA in central mineralocorticoid hypertension. Hypertension (1997) 30:953–956.[Abstract/Free Full Text]
  21. Matsumura K., Abe I., Tsuchihashi T., Fujishima N. Central nitric oxide attenuates the baroreceptor reflex in conscious rabbits. Am J Physiol Regul Integr Comp Physiol (1998) 43:R1142–R1149.
  22. Zanzinger J., Czachurski J., Seller H. Neuronal nitric oxide reduces sympathetic excitability by modulation of central glutamate effects in pigs. Circ Res (1997) 80:565–571.[Abstract/Free Full Text]
  23. Liu J.L., Murakami H., Zucker I.H. Angiotensin II nitric oxide interaction on sympathetic outflow in conscious rabbits. Circ Res (1998) 82:496–502.[Abstract/Free Full Text]
  24. Garthwaite J., Garthwaite G., Palmer R.M.J., Moncada S. NMDA receptor activation induces nitric oxide synthesis from arginine in rat brain slices. Eur J Pharmacol (1989) 172:413–416.[CrossRef][Web of Science][Medline]
  25. Faraci F.M., Breese K.R. Nitric oxide mediates vasodilatation in response to activation of N-methyl-D-aspartate receptors in brain. Circ Res (1993) 72:476–480.[Abstract/Free Full Text]
  26. Hirooka Y., Polson J.W., Dampney R.A.L. Pressor and sympathoexcitatory effects of nitric oxide in the rostral ventrolateral medulla. J Hypertension (1996) 14:1317–1324.[CrossRef][Web of Science][Medline]
  27. Martinspringe M.C., Baraldipassy I., Lopes O.U. Excitatory effects of nitric oxide within the rostral ventrolateral medulla of freely moving rats. Hypertension (1997) 30(2):704–707.[Abstract/Free Full Text]
  28. Zanzinger J., Czachurski J., Seller H. Inhibition of sympathetic vasoconstriction is a major principle of vasodilation by nitric oxide in vivo. Circ Res (1994) 75:1073–1077.[Abstract/Free Full Text]
  29. Sun M.K., Guyenet P.G. GABA-mediated baroreceptor inhibition of reticulospinal neurons. Am J Physiol (1985) 249:R672–R680.[Web of Science][Medline]
  30. Sved A.F., Gordon F.J. Amino acids as central neurotransmitters in the baroreceptor reflex pathway. News Physiol Sci (1994) 9:243–246.[Abstract/Free Full Text]
  31. Harada S., Tokunaga S., Momohara M., et al. Inhibition of nitric oxide formation in the nucleus tractus solitarius increases renal sympathetic nerve activity in rabbits. Circ Res (1993) 72:511–516.[Abstract/Free Full Text]
  32. Tagawa T., Imaizumi T., Harada S., et al. Nitric oxide influences neuronal activity in the nucleus tractus solitarius of rat brainstem slices. Circ Res (1994) 75:70–76.[Abstract/Free Full Text]
  33. Ma S., Abboud F.M., Felder R.B. Effects of L-arginine-derived nitric oxide synthesis on neuronal activity in nucleus tractus solitarius. Am J Physiol Regul Integr Comp Physiol (1995) 268:R487–R491.[Abstract/Free Full Text]
  34. Ogawa H., Mizusawa A., Kikuchi Y., et al. Nitric oxide as a retrograde messenger in the nucleus tractus solitarii of rats during hypoxia. J Physiol (Lond) (1995) 486:495–504.[Abstract/Free Full Text]
  35. Andresen M.C., Kunze D.L. Nucleus tractus solitarius – Gateway to neural circulatory control. Annu Rev Physiol (1994) 56:93–116.[Web of Science][Medline]
  36. Garthwaite J. Neural nitric oxide signalling. Trends Neurosci (1995) 18:51–52.[CrossRef][Web of Science][Medline]
  37. Schmid H.A., Pehl U. Regional specific effects of nitric oxide donors and cGMP on the electrical activity of neurons in the rat spinal cord. J Chem Neuroanatomy (1996) 10:197–201.[CrossRef][Web of Science][Medline]
  38. Chen K., Hernandez Y.M., Dretchen K.L., Gillis R.A. Intravenous NBQX inhibits spontaneously occurring sympathetic nerve activity and reduces blood pressure in cats. Eur J Pharmacol (1994) 252:155–160.[CrossRef][Web of Science][Medline]
  39. Hong Y.G., Henry J.L. Glutamate, NMDA and NMDA receptor antagonists: cardiovascular effects of intrathecal administration in the rat. Brain Res (1992) 569:38–45.[CrossRef][Web of Science][Medline]
  40. Chen S.Y., Wu W.C., Tseng C.J., Kuo J.S., Chai C.Y. Involvement of non-NMDA and NMDA receptors in glutamate-induced pressor or depressor responses of the pons and medulla. Clin Exp Pharmacol Physiol (1997) 24:46–56.[Web of Science][Medline]
  41. Sakuma I., Togashi H., Yoshioka M., et al. NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity invivo-A role for nitric oxide in the central regulation of sympathetic tone. Circ Res (1992) 70:607–611.[Abstract/Free Full Text]
  42. Cunha R.S., Cabral A.M., Vasquez E.C. Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats. Am J Hypertens (1993) 6:806–809.[Web of Science][Medline]
  43. Sander M., Hansen P.G., Victor R.G. Sympathetically mediated hypertension caused by chronic inhibition of nitric oxide. Hypertension (1995) 26:691–695.[Abstract/Free Full Text]
  44. Kumagai H., Averill D.B., Khosla M.C., Ferrario C.M. Role of nitric oxide and angiotensin II in the regulation of sympathetic nerve activity in spontaneously hypertensive rats. Hypertension (1993) 21:476–484.[Abstract/Free Full Text]
  45. Hansen J., Jacobsen T.N., Victor R.G. Is nitric oxide involved in the tonic inhibition of central sympathetic outflow in humans. Hypertension (1994) 24:439–444.[Abstract/Free Full Text]
  46. Castellano M., Rizzoni D., Beschi M., et al. Relationship between sympathetic nervous system activity, baroreflex and cardiovascular effects after acute nitric oxide synthesis inhibition in humans. J Hypertens (1995) 13:1153–1161.[CrossRef][Web of Science][Medline]
  47. Häbler H.J., Wasner G., Bartsch T., Janig W. Responses of rat postganglionic sympathetic vasoconstrictor neurons following blockade of nitric oxide synthesis in vivo. Neuroscience (1997) 77:899–909.[CrossRef][Web of Science][Medline]
  48. Pegoraro A.A., Carretero O.A., Sigmon D.H., Beierwaltes W.H. Sympathetic modulation of endothelium-derived relaxing factor. Hypertension (1992) 19:643–647.[Abstract/Free Full Text]
  49. Jimbo M., Suzuki H., Ichikawa M., et al. Role of nitric oxide in regulation of baroreceptor reflex. J Auton Nerv Syst (1994) 50:209–219.[CrossRef][Web of Science][Medline]
  50. Liu J.L., Murakami H., Zucker I.H. Effects of NO on baroreflex control of heart rate and renal nerve activity in conscious rabbits. Am J Physiol Regul Integr Comp Physiol (1996) 39:R1361–R1370.
  51. Hirai T., Musch T.I., Morgan D.A., et al. Differential sympathetic nerve responses to nitric oxide synthase inhibition in anesthetized rats. Am J Physiol Regul Integr Comp Physiol (1995) 269:R807–R813.[Abstract/Free Full Text]
  52. Kirchheim H.R. Systemic arterial baroreceptor reflexes. Physiol Rev (1976) 56:100–176.[Free Full Text]
  53. Seller H. Baroreceptor reflexes. Integrative functions and clinical aspects. Persson P.B., Kirchheim H.R., eds. (1991) Heidelberg: Springer. 45–74.
  54. Moreira E.D., Ida F., Krieger E.M. Extent of rapid baroreceptor resetting during 1st hours of hypertension. Am J Physiol (1989) 257:H711–H716.[Web of Science][Medline]
  55. Brunner M.J., Kligman M.D. Rapid resetting of baroreflexes in hypertensive dogs. Am J Physiol (1992) 262:H1508–H1514.[Web of Science][Medline]
  56. Chen H.I., Chang K.C., Liu H.C., Lin C.H. Acute adaptation and resetting of the baroreflex control of vascular resistance in the canine hindquarters and mesentery. Pflugers Arch (1993) 424:276–284.[CrossRef][Web of Science][Medline]
  57. Kunze D.L. Acute resetting of baroreceptor reflex in rabbits: a central component. Am J Physiol (1986) 250:H866–H870.[Web of Science][Medline]
  58. Patel K.P., Zhang K., Zucker I.H., Krukoff T.L. Decreased gene expression of neuronal nitric oxide synthase in hypothalamus and brainstem of rats in heart failure. Brain Res (1996) 734:109–115.[Web of Science][Medline]
  59. Liu Q.S., Jia Y.S., Ju G. Nitric oxide inhibits neuronal activity in the supraoptic nucleus of the rat hypothalamic slices. Brain Res Bull (1997) 43:121–125.[CrossRef][Web of Science][Medline]
  60. Goodson A.R., Leibold J.M., Gutterman D.D. Inhibition of nitric oxide synthesis augments centrally induced sympathetic coronary vasoconstriction in cats. Am J Physiol Heart Circ Physiol (1994) 267:H1272–H1278.[Abstract/Free Full Text]
  61. Scrogin K.E., Hatton D.C., Chi Y., Luft F.C. Chronic nitric oxide inhibition with L-NAME: effects on autonomic control of the cardiovascular system. Am J Physiol Regul Integr Comp Physiol (1998) 43:R367–R374.
  62. Koch M.A., Hasser E.M., Schadt J.C. Influence of nitric oxide on the hemodynamic response to hemorrhage in conscious rabbits. Am J Physiol Regul Integr Comp Physiol (1995) 268:R171–R182.[Abstract/Free Full Text]
  63. Zanzinger J., Bassenge E. Low dose calcium-antagonism compensates for impaired myocardial blood supply resulting from deficient nitric oxide synthesis. Naunyn Schmiedebergs Arch Pharmacol (1994) 350:185–188.[Web of Science][Medline]
  64. Ruggiero D.A., Mtui E.P., Otake K., Anwar M. Central and primary visceral afferents to nucleus tractus solitarii may generate nitric oxide as a membrane permeant neuronal messenger. J Comp Neurol (1996) 364:51–67.[CrossRef][Web of Science][Medline]
  65. Esplugues J.V., Barrachina M.D., Beltran B., et al. Inhibition of gastric acid secretion by stress: a protective reflex mediated by cerebral nitric oxide. Proc Natl Acad Sci USA (1996) 93:14839–14844.[Abstract/Free Full Text]
  66. Panico W.H., Cavuto N.J., Kallimanis G., et al. Functional evidence for the presence of nitric oxide synthase in the dorsal motor nucleus of the vagus. Gastroenterology (1995) 109:1484–1491.[CrossRef][Web of Science][Medline]
  67. Gai W.-P., Messenger J.P., Yu Y.-H., Gieroba Z.J., Blessing W.W. Nitric oxide-synthesising neurons in the central subnucleus of the nucleus tractus solitarius provide a major innervation of the rostral nucleus ambiguus in the rabbit. J Comp Neurol (1995) 357:348–361.[CrossRef][Web of Science][Medline]
  68. Murakami H., Liu J.L., Yoneyama H., et al. Blockade of neuronal nitric oxide synthase alters the baroreflex control of heart rate in the rabbit. Am J Physiol Regul Integr Comp Physiol (1998) 43:R181–R186.
  69. Zanzinger J., Czachurski J., Seller H. Nitric oxide in the ventrolateral medulla regulates sympathetic responses to systemic hypoxia in pigs. Am J Physiol (1998) 275:R33–R39.[Web of Science][Medline]
  70. Gozal D., Gozal E., Gozal Y.M., Torres J.E. Nitric oxide synthase isoforms and peripheral chemoreceptor stimulation in conscious rats. NeuroReport (1996) 7:1145–1148.[Web of Science][Medline]
  71. Wang Z.-Z., Stensaas L.J., Dinger B.G., Fidone S.J. Nitric oxide mediates chemoreceptor inhibition in the cat carotid body. Neuroscience (1995) 65:217–229.[CrossRef][Web of Science][Medline]
  72. Trzebski A., Sato Y., Suzuki A., Sato A. Inhibition of nitric oxide synthesis potentiates the responsiveness of carotid chemoreceptors to systemic hypoxia in the rat. Neurosci Lett (1995) 190:29–32.[CrossRef][Web of Science][Medline]
  73. Marshall J.M. Chemoreceptors and cardiovascular control in acute and chronic systemic hypoxia. Braz J Med Biol Res (1998) 31:863–888.[Web of Science][Medline]
  74. Prabhakar N.R., Kumar G.K., Chang C.H., Agani F.H., Haxhiu M.A. Nitric oxide in the sensory function of the carotid body. Brain Res (1993) 625:16–22.[CrossRef][Web of Science][Medline]
  75. Li J.H., Potts J.T., Mitchell J.H. Effect of barodenervation on c-Fos expression in the medulla induced by static muscle contraction in cats. Am J Physiol Heart Circ Physiol (1998) 43:H901–H908.
  76. Potts J.T., Hand G.A., Li J.H., Mitchell J.H. Central interaction between carotid baroreceptors and skeletal muscle receptors inhibits sympathoexcitation. J Appl Physiol (1998) 84:1158–1165.[Abstract/Free Full Text]
  77. Li W.M., Sato A., Suzuki A. The inhibitory role of nitric oxide (NO) in the somatocardiac sympathetic C-reflex in anesthetized rats. Neurosci Res (1995) 22:375–380.[CrossRef][Web of Science][Medline]
  78. Araujo M.T.M., Barker L.A., Cabral A.M., Vasquez E.C. Inhibition of nitric oxide synthase causes profound enhancement of the Bezold-Jarisch reflex. Am J Hypertens (1998) 11(Part 1):66–72.[CrossRef][Web of Science][Medline]
  79. Spyer K.M. Neural organisation and control of the baroreceptor reflex. Rev Physiol Biochem Pharmacol (1981) 88:23–124.[CrossRef]
  80. Minami N., Imai Y., Hashimoto J.I., Abe K. The role of nitric oxide in the baroreceptor-cardiac reflex in conscious Wistar rats. Am J Physiol Heart Circ Physiol (1995) 269:H851–H855.[Abstract/Free Full Text]
  81. Scrogin K.E., Veelken R., Luft F.C. Sympathetic baroreceptor responses after chronic NG- nitro-L-arginine methyl ester treatment in conscious rats. Hypertension (1994) 23:982–986.[Abstract/Free Full Text]
  82. Matsuda T., Bates J.N., Lewis S.J., Abboud F.M., Chapleau M.W. Modulation of baroreceptor activity by nitric oxide and S-nitrosocysteine. Circ Res (1995) 76:426–433.[Abstract/Free Full Text]
  83. Li Z., Chapleau M.W., Bates J.N., et al. Nitric oxide as an autocrine regulator of sodium currents in baroreceptor neurons. Neuron (1998) 20:1039–1049.[CrossRef][Web of Science][Medline]
  84. Zanzinger J., Czachurski J., Seller H. Lack of nitric oxide sensitivity of carotid sinus baroreceptors activated by normal blood pressure stimuli in cats. Neurosci Lett (1996) 208:121–124.[CrossRef][Web of Science][Medline]
  85. Zanzinger J., Czachurski J., Seller H. Effects of nitric oxide on sympathetic baroreflex transmission in the nucleus tractus solitarii and caudal ventrolateral medulla in cats. Neurosci Lett (1995) 197:199–202.[CrossRef][Web of Science][Medline]
  86. Armour J.A., Murphy D.A., Yuan B.-X., MacDonald S., Hopkins D.A. Gross and microscopic anatomy of the human intrinsic cardiac nervous system. The Anatomical Record (1997) 247:289–298.[CrossRef][Medline]
  87. Armour J.A. Cardiac effects of electrically induced intrathoracic autonomic reflexes. Can J Physiol Pharmacol (1988) 66:714–720.[Web of Science][Medline]
  88. Armour J.A., Smith F.M., Losier A.M., Ellenberger H.H., Hopkins D.A. Modulation of intrinsic cardiac neuronal activity by nitric oxide donors induces cardiodynamic changes. Am J Physiol Regul Integr Comp Physiol (1995) 268:R403–R413.[Abstract/Free Full Text]
  89. Horackova M., Armour J.A., Hopkins D.A., Huang M.H. Nitric oxide modulates signaling between cultured adult peripheral cardiac neurons and cardiomyocytes. Am J Physiol Cell Physiol (1995) 269:C504–C510.[Abstract/Free Full Text]
  90. Broten T.P., Miyashiro J.K., Moncada S., Feigl E.O. Role of endothelium-derived relaxing factor in parasympathetic coronary vasodilation. Am J Physiol (1992) 262:H1579–H1584.[Web of Science][Medline]
  91. Yabe M., Nishikawa K., Terai T., Yukioka H., Fujimori M. The effects of intrinsic nitric oxide on cardiac neural regulation in cats. Anesth Analg (1998) 86:1194–1200.[Abstract]
  92. Han X., Shimoni Y., Giles W.R. An obligatory role for nitric oxide in autonomic control of mammalian heart rate. J Physiol (Lond) (1994) 476:309–314.[Abstract/Free Full Text]
  93. Zhao G., Xu X.B., Ochoa M., Shen W.Q., Hintze T.H. Interaction between prostacyclin and nitric oxide in the reflex control of the coronary circulation in conscious dogs. Cardiovasc Res (1996) 32:940–948.[Abstract/Free Full Text]
  94. Zhao G., Zhang X.P., Xu X.B., Ochoa M., Hintze T.H. Short term exercise training enhances reflex cholinergic nitric oxide dependent coronary vasodilation in conscious dogs. Circ Res (1997) 80:868–876.[Abstract/Free Full Text]
  95. Schwarz P., Diem R., Dun N.J., Förstermann U. Endogenous and exogenous nitric oxide inhibits norepinephrine release from rat heart sympathetic nerves. Circ Res (1995) 77:841–848.[Abstract/Free Full Text]
  96. Addicks K., Bloch W., Feelisch M. Nitric oxide modulates sympathetic neurotransmission at the prejunctional level. Microsc Res Tech (1994) 29:161–168.[CrossRef][Web of Science][Medline]
  97. Hare J.M., Givertz M.M., Creager M.A., Colucci W.S. Increased sensitivity to nitric oxide synthase inhibition in patients with heart failure: Potentiation of beta-adrenergic inotropic responsiveness. Circulation (1998) 97:161–166.[Abstract/Free Full Text]
  98. Hare J.M., Loh E., Creager M.A., Colucci W.S. Nitric oxide inhibits the positive inotropic response to β-adrenergic stimulation in humans with left ventricular dysfunction. Circulation (1995) 92:2198–2203.[Abstract/Free Full Text]
  99. Kim S.J., Ghaleh B., Kudejrk K., et al. Delayed enhanced nitric oxide mediated coronary vasodilation following brief ischemia and prolonged reperfusion in conscious dogs. Circ Res (1997) 81:53–59.[Abstract/Free Full Text]
  100. Hasebe N., Shen Y.-T., Vatner S.F. Inhibition of endothelium-derived relaxing factor enhances myocardial stunning in conscious dogs. Circulation (1993) 88:2862–2871.[Abstract/Free Full Text]
  101. Kooy N.W., Lewis S.J., Royall J.A., et al. Extensive tyrosine nitration in human myocardial inflammation: evidence for the presence of peroxynitrite. Crit Care Med (1997) 25:812–819.[CrossRef][Web of Science][Medline]
  102. Vo P.A., Reid J.J., Rand M.J. Endothelial nitric oxide attenuates vasoconstrictor responses to nerve stimulation and noradrenaline in the rat tail artery. Eur J Pharmacol (1991) 199:123–125.[CrossRef][Web of Science][Medline]
  103. Tesfamarian B., Cohen R.A. Inhibition of adrenergic vasoconstriction by endothelial shear stress. Circ Res (1988) 63:720–725.[Abstract/Free Full Text]
  104. Maclean M.R., McCulloch K.M., Mcgrath J.C. Influences of the endothelium and hypoxia on {alpha}1- and {alpha}2-adrenoceptor-mediated responses in the rabbit isolated pulmonary artery. Br J Pharmacol (1993) 108:155–161.[Web of Science][Medline]
  105. Tesfamariam B., Weisbrod R.M., Cohen R.A. Augmented adrenergic contractions of carotid arteries from cholesterol-fed rabbits due to endothelial cell dysfunction. J Cardiovasc Pharmacol (1989) 13:820–825.[Web of Science][Medline]
  106. Thorin E., Atkinson J. Modulation by the endothelium of sympathetic vasoconstriction in an in vitro preparation of the rat tail artery. Br J Pharmacol (1994) 111:351–357.[Web of Science][Medline]
  107. Toda N., Kitamura Y., Okamura T. Neural mechanism of hypertension by nitric oxide synthase inhibitor in dogs. Hypertension (1993) 21:3–8.[Abstract/Free Full Text]
  108. Maclean M.R., Graham J., Mcgrath J.C. Endogenous nitric oxide modulates vasopressor responses, but not depressor responses, to spinal sympathetic nerve stimulation in pithed rats. J Cardiovasc Pharmacol (1994) 23:319–325.[Web of Science][Medline]
  109. Vanhoutte P.M., Rubanyi G.M., Miller V.M., Houston D.S. Modulation of vascular smooth muscle contraction by the endothelium. Annu Rev Physiol (1986) 48:307–320.[CrossRef][Web of Science][Medline]
  110. Thomas G.D., Victor R.G. Nitric oxide mediates contraction-induced attenuation of sympathetic vasoconstriction in rat skeletal muscle. J Physiol -London (1998) 506:817–826.[Abstract/Free Full Text]
  111. Toda N., Okamura T. Neurogenic nitric oxide (NO) in the regulation of cerebroarterial tone. J Chem Neuroanatomy (1996) 10:259–265.[CrossRef][Web of Science][Medline]
  112. Yoshida K., Okamura T., Kimura H., et al. Nitric oxide synthase-immunoreactive nerve fibers in dog cerebral and peripheral arteries. Brain Res (1993) 629:67–72.[CrossRef][Web of Science][Medline]
  113. Toda N., Matsumoto T., Yoshida K. Comparison of hypoxia-induced contraction in human, monkey, and dog coronary arteries. Am J Physiol (1992) 262:H678–H683.[Web of Science][Medline]
  114. Barroso C.P., Edvinsson L., Zhang W., et al. Nitroxidergic innervation of guinea pig cerebral arteries. J Auton Nerv Syst (1996) 58:108–114.[CrossRef][Web of Science][Medline]
  115. Ekelund U., Mellander S. Endogenous nitric oxide as a physiological regulator of vascular tone in cat skeletal muscle during haemorrhage. Acta Physiol Scand (1996) 157:471–479.[CrossRef][Web of Science][Medline]
  116. Mellander S., Bjornberg J., Ekelund U., Alm P. Cardiovascular regulation by endogenous nitric oxide is essential for survival after acute haemorrhage. Acta Physiol Scand (1997) 160:57–65.[Web of Science][Medline]
  117. Davisson R.L., Shaffer R.A., Johnson A.K., Lewis S.J. Stimulation of lumbar sympathetic nerves may produce hindlimb vasodilation via the release of pre formed stores of nitrosyl factors. Neuroscience (1996) 72:881–887.[CrossRef][Web of Science][Medline]
  118. Booke M., Waurick R., VanAken H., et al. Effects of sympathetic nerve blockade on vasoconstrictive properties of nitric oxide synthase inhibition in sheep. Cardiovasc Res (1997) 36:111–117.[Abstract/Free Full Text]
  119. Dirnagl U., Niwa K., Lindauer U., Villringer A. Coupling of cerebral blood flow to neuronal activation: Role of adenosine and nitric oxide. Am J Physiol Heart Circ Physiol (1994) 267:H296–H301.[Abstract/Free Full Text]
  120. Akgoren N., Fabricius M., Lauritzen M. Importance of nitric oxide for local increases of blood flow in rat cerebellar cortex during electrical stimulation. Proc Natl Acad Sci USA (1994) 91:5903–5907.[Abstract/Free Full Text]
  121. Li J., Iadecola C. Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex. Neuropharmacology (1994) 33:1453–1461.[CrossRef][Web of Science][Medline]
  122. Meng W., Tobin J.R., Busija D.W. Glutamate-induced cerebral vasodilation is mediated by nitric oxide through N-methyl-D-aspartate receptors. Stroke (1995) 26:857–862.[Abstract/Free Full Text]
  123. Yang S.T., Chang H.H. Nitric oxide of neuronal origin mediates NMDA-induced cerebral hyperemia in rats. Neuroreport (1998) 9:415–418.[Web of Science][Medline]
  124. Gonzalez C., Estrada C. Nitric oxide mediates the neurogenic vasodilation of bovine cerebral arteries. J Cereb Blood Flow Metab (1991) 11:366–370.[Web of Science][Medline]
  125. Toda N., Okamura T. Neurogenic nitric oxide (NO) in the regulation of cerebroarterial tone. J Chem Neuroanat (1996) 10:259–265.[CrossRef][Web of Science][Medline]
  126. Goadsby P.J., Uddman R., Edvinsson L. Cerebral vasodilatation in the cat involves nitric oxide from parasympathetic nerves. Brain Res (1996) 707:110–118.[CrossRef][Web of Science][Medline]
  127. Iadecola C. Does nitric oxide mediate the increases in cerebral blood flow elicited by hypercapnia? Proc Natl Acad Sci USA (1992) 89:3913–3916.[Abstract/Free Full Text]
  128. Fabricius M., Rubin I., Bundgaard M., Lauritzen M. NOS activity in brain and endothelium: relation to hypercapnic rise of cerebral blood flow in rats. Am J Physiol (1996) 271:H2035–H2044.[Web of Science][Medline]
  129. You J.P., Wang Q., Zhang W., et al. Hypercapnic vasodilatation in isolated rat basilar arteries is exerted via low pH and does not involve nitric oxide synthase stimulation or cyclic GMP production. Acta Physiol Scand (1994) 152:391–397.[Web of Science][Medline]
  130. Irikura K., Huang P.L., Ma J., et al. Cerebrovascular alterations in mice lacking neuronal nitric oxide synthase gene expression. Proc Natl Acad Sci USA (1995) 92:6823–6827.[Abstract/Free Full Text]
  131. Iadecola C., Zhang F. Permissive and obligatory roles of NO in cerebrovascular responses to hypercapnia and acetylcholine. Am J Physiol (1996) 271:R990–1001.[Web of Science][Medline]
  132. Thompson B.G., Pluta R.M., Girton M.E., Oldfield E.H. Nitric oxide mediation of chemoregulation but not autoregulation of cerebral blood flow in primates. J Neurosurg (1996) 84:71–78.[Web of Science][Medline]
  133. Ignarro L.J., Bush P.A., Buga G.M., et al. Nitric oxide and cyclic GMP formation upon electrical field stimulation cause relaxation of corpus cavernosum smooth muscle. Biochem Biophys Res Commun (1990) 170:843–850.[CrossRef][Web of Science][Medline]
  134. Rajfer J., Aronson W.J., Bush P.A., Dorey F.J., Ignarro L.J. Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission. N Engl J Med (1992) 326:90–94.[Abstract]
  135. Ehmke H., Junemann K.P., Mayer B., Kummer W. Nitric oxide synthase and vasoactive intestinal polypeptide colocalization in neurons innervating the human penile circulation. Int J Impot Res (1995) 7:147–156.[Medline]
  136. Dail W.G., Barba V., Leyba L., Galindo R. Neural and endothelial nitric oxide synthase activity in rat penile erectile tissue. Cell Tissue Res (1995) 282:109–116.[Web of Science][Medline]
  137. Pickard R.S., Powell P.H., Zar M.A. Nitric oxide and cyclic GMP formation following relaxant nerve stimulation in isolated human corpus cavernosum. Br J Urol (1995) 75:516–522.[Web of Science][Medline]
  138. Majewski M., Sienkiewicz W., Kaleczyc J., et al. The distribution and co-localization of immunoreactivity to nitric oxide synthase, vasoactive intestinal polypeptide and substance P within nerve fibres supplying bovine and porcine female genital organs. Cell Tissue Res (1995) 281:445–464.[CrossRef][Web of Science][Medline]
  139. Hoyle C.H.V., Stones R.W., Robson T., Whitley K., Burnstock G. Innervation of vasculature and microvasculature of the human vagina by NOS and neuropeptide containing nerves. J Anatomy (1996) 18(Part 3):633–644.
  140. Morales A., Gingell C., Collins M., Wicker P.A., Osterloh I.H. Clinical safety of oral sildenafil citrate (VIAGRA) in the treatment of erectile dysfunction. Int J Impot Res (1998) 10:69–73.[CrossRef][Web of Science][Medline]
  141. Rosselli M., Keller P.J., Dubey R.K. Role of nitric oxide in the biology, physiology and pathophysiology of reproduction. Hum Reprod Update (1998) 4:3–24.[Abstract/Free Full Text]
  142. Benarroch E.E., Smithson I.L. Distribution and relationships of neuropeptide Y and NADPH diaphorase in human ventrolateral medulla oblongata. J Autonom Nerv Syst (1997) 62:143–146.[CrossRef][Web of Science][Medline]
  143. Gai W.P., Blessing W.W. Human brainstem preganglionic parasympathetic neurons localized by markers for nitric oxide synthesis. Brain (1996) 119(Part. 4):1145–1152.[Abstract/Free Full Text]
  144. Bernstein H.G., Stanarius A., Baumann B., et al. Nitric oxide synthase-containing neurons in the human hypothalamus: Reduced number of immunoreactive cells in the paraventricular nucleus of depressive patients and schizophrenics. Neuroscience (1998) 83:867–875.[CrossRef][Web of Science][Medline]
  145. Funk R.H.W., Mayer B., Wörl J. Nitrergic innervation and nitrergic cells in arteriovenous anastomoses. Cell Tissue Res (1994) 277:477–484.[Web of Science][Medline]
  146. Tomimoto H., Nishimura M., Suenaga T., et al. Distribution of nitric oxide synthase in the human cerebral blood vessels and brain tissues. J Cereb Blood Flow Metab (1994) 14:930–938.[Web of Science][Medline]
  147. Burnett A.L., Tillman S.L., Chang T.S.K., et al. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J Urol (1993) 150:73–76.[Web of Science][Medline]
  148. Bush P.A., Aronson W.J., Buga G.M., Rajfer J., Ignarro L.J. Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum. J Urology (1992) 147:1650–1655.[Web of Science][Medline]
  149. Dietz N.M., Rivera J.M., Eggener S.E., et al. Nitric oxide contributes to the rise in forearm blood flow during mental stress in humans. J Physiol (Lond) (1994) 480:361–368.[Abstract/Free Full Text]
  150. Fabi F., Argiolas L., Chiavarelli M., Delbasso P. Nitric oxide dependent and independent modulation of smpathethtic vasoconstriction in the human saphenous vein. Eur J Pharmacol (1996) 309:41–50.[CrossRef][Web of Science][Medline]
  151. Green D.J., Odriscoll G., Blanksby B.A., Taylor R.R. Control of skeletal muscle blood flow during dynamic exercise: Contribution of endothelium derived nitric oxide. Sports Med (1996) 21:119–146.[Web of Science][Medline]
  152. Skarphedison J.O., Elam M., Jungersten L., Wallin B.G. Sympathetic nerve traffic correlates with the release of nitric oxide in humans: Implications for blood pressure control. J Physiol-Lond (1997) 501(Part 3):671–675.[Abstract/Free Full Text]
  153. Jia L., Bonaventura C., Bonaventura J., Stamler J.S. S-Nitrosohemoglobin-A dynamic activity of blood involved in vascular control. Nature (1996) 380:221–226.[CrossRef][Medline]
  154. Boese M., Mordvintcev P.I., Vanin A.F., Busse R., Mülsch A. S-nitrosation of serum albumin by dinitrosyl-iron complex. J Biol Chem (1995) 270:29244–29249.[Abstract/Free Full Text]
  155. Gómez-Jiménez J., Salgado A., Mourelle M., et al. L-arginine: Nitric oxide pathway in endotoxemia and human septic shock. Crit Care Med (1995) 23:253–258.[CrossRef][Web of Science][Medline]
  156. Klemm P., Thiemermann C., Winklmaier G., Martorana P.A., Henning R. Effects of nitric oxide synthase inhibition combined with nitric oxide inhalation in a porcine model of endotoxin shock. Br J Pharmacol (1995) 114:363–368.[Web of Science][Medline]
  157. Schulz R., Panas D.L., Catena R., et al. The role of nitric oxide in cardiac depression induced by interleukin-1β and tumour necrosis factor-{alpha}. Br J Pharmacol (1995) 114:27–34.[Web of Science][Medline]
  158. Sun X.L., Wei S., Szabo C., Dusting G.J. Depression of the inotropic action of isoprenaline by nitric oxide synthase induction in rat isolated hearts. Eur J Pharmacol (1997) 320:29–35.[CrossRef][Web of Science][Medline]
  159. Seo H.G., Fujiwara N., Kaneto H., et al. Effect of a nitric oxide synthase inhibitor, s ethylisothiourea, on cultured cells and cardiovascular functions of normal and lipopolysaccharide treated rabbits. J Biochem (1996) 119:553–558.[Abstract/Free Full Text]
  160. Stamler J.S. Hausladen A Oxidative modifications in nitrosative stress. Nat Struc Biol (1998) 5:247–249.[CrossRef][Web of Science][Medline]
  161. Brune B., vonKnethen A., Sandau K.B. Nitric oxide and its role in apoptosis. Eur J Pharmacol (1998) 351(SI):261–272.[CrossRef][Web of Science][Medline]
  162. Michaelis E.K. Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging. Progr Neurobiol (1998) 54:369–415.[CrossRef][Web of Science][Medline]
  163. Zanzinger J., Czachurski J., Seller H. Impaired modulation of sympathetic excitability by nitric oxide after long-term administration of organic nitrates in pigs. Circulation (1998) 97:2352–2358.[Abstract/Free Full Text]
  164. Dibona G.F., Jones S.Y., Sawin L.L. Effect of endogenous Angiotensin II on renal nerve activity and its arterial baroreflex regulation. Am J Physiol Regul Integr Comp Physiol (1996) 40:R361–R367.
  165. Bendle R.D., Malpas S.C., Head G.A. Role of endogenous Angiotensin II on sympathetic reflexes in conscious rabbits. Am J Physiol Regul Integr Comp Physiol (1997) 41:R1816–R1825.
  166. Xu L., Brooks V.L. Ang. II chronically supports renal and lumbar sympathetic activity in sodium deprived, conscious rats. Am J Physiol Heart Circ Physiol (1996) 40:H2591–H2598.
  167. Matsukawa T., Mano T., Gotoh E., Ishii M. Elevated sympathetic nerve activity in patients with accelerated essential hypertension. J Clin Invest (1993) 92:25–28.[Web of Science][Medline]
  168. Hirooka Y., Dampney R.A.L. Endogenous angiotensin within the rostral ventrolateral medulla facilitates the somatosympathetic reflex. J Hypertens (1995) 13:747–754.[Web of Science][Medline]
  169. Ito S., Sved A.F. Blockade of Angiotensin receptors in rat rostral ventrolateral medulla removes excitatory vasomotor tone. Am J Physiol Regul Integr Comp Physiol (1996) 39:R1317–R1323.
  170. Murakami H., Liu J.L., Zucker I.H. Angiotensin II enhances baroreflex control of sympathetic outflow in heart failure. Hypertension (1997) 29:564–569.[Abstract/Free Full Text]
  171. Rajagopalan S., Kurz S., Munzel T., et al. Angiotensin II mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J Clin Invest (1996) 97:1916–1923.[Web of Science][Medline]
  172. Krukoff T.L., Gehlen F., Ganten D., Wagner J. Gene expression of brain nitric oxide synthase and soluble guanylyl cyclase in hypothalamus and medulla of two-kidney, one clip hypertensive rats. Hypertension (1995) 26:171–176.[Abstract/Free Full Text]
  173. Alaghbandzadeh J., Das I., Hanson M.R., et al. Hypothalamic and plasma total nitrate/nitrite concentrations in spontaneously hypertensive rats. Exp Physiol (1996) 81:881–883.[Abstract]
  174. Tang F.R., Tan C.K., Ling E.A. A comparative study of NADPH-diaphorase in the sympathetic preganglionic neurons of the upper thoracic cord between spontaneously hypertensive rats and Wistar-Kyoto rats. Brain Res (1995) 691:153–159.[CrossRef][Web of Science][Medline]
  175. Nava E., Farre A.L., Moreno C., et al. Alterations to the nitric oxide pathway in the spontaneously hypertensive rat. J. Hypertens (1998) 16:609–615.[CrossRef][Web of Science][Medline]
  176. Kelm M., Feelisch M., Krebber T., Motz W., Strauer B.E. The role of nitric oxide in the regulation of coronary vascular resistance in arterial hypertension: Comparison of normotensive and spontaneously hypertensive rats. J Cardiovasc Pharmacol. (1992) 20(Suppl. 12):S183–S186.[Web of Science][Medline]
  177. Hörl W.H., Riegel W. Cardiac depressant factors in renal disease. Circulation (1993) 87(Suppl. 4):IV77–IV82.[Medline]
  178. Schnakenberg C.G., Welch W.J., Wilcox C.S. Normalization of blood pressure and renal vascular resistance in SHR with a membrane-permeable superoxide dismutase mimetic: Role of nitric oxide. Hypertension (1998) 32:59–64.[Abstract/Free Full Text]
  179. Wiemer G., Linz W., Hatrik S., Scholkens B.A., Malinski T. Angiotensin converting enzyme inhibition alters nitric oxide and superoxide. Hypertension (1997) 30:1183–1190.[Abstract/Free Full Text]
  180. D’Amico M., Berrino L., Filippelli A., Maione S., Rossi F. Relation between L-arginine-nitric oxide pathway and endothelin-1 effects in periaqueductal gray area of rats. J Cardiovasc Pharmacol (1994) 24:974–978.[Web of Science][Medline]
  181. Zhang J., Snyder S.H. Nitric oxide in the nervous system. Annu Rev Pharmacol Toxicol (1995) 35:213–233.[CrossRef][Web of Science][Medline]
  182. Nelson R.J., Kriegsfeld L.J., Dawson V.L., Dawson T.M. Effects of nitric oxide on neuroendocrine function and behavior. Frontiers Neuroendocrinology (1997) 18:463–491.[CrossRef]
  183. Yun H.Y., Dawson V.L., Dawson T.M. Nitric oxide in health and disease of the nervous system. Mol Psychiatry (1997) 2:300–310.[CrossRef][Web of Science][Medline]

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