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Cardiovascular Research Advance Access originally published online on June 22, 2009
Cardiovascular Research 2009 84(1):11-14; doi:10.1093/cvr/cvp210
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Neglect of the coronary circulation: some critical remarks on problems in the translation of cardioprotection

Gerd Heusch* and Rainer Schulz

Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany

* Corresponding author. Tel: +49 201 723 4480; fax: +49 201 723 4481. E-mail address: gerd.heusch@uk-essen.de

The first 150 words of the full text of this article appear below.

Acute myocardial infarction remains a significant health problem throughout the world, and for those patients surviving the immediate event, infarct size is the main determinant of further prognosis.1–3 Timely reperfusion, as originally reported in dogs by John Ross Jr over 30 years ago,4–6 is still the only way to reduce ultimate infarct size but comes also at a price and induces injury in itself.7,8 Ischaemic preconditioning and ischaemic postconditioning, again originally both reported in dogs,9,10 reduce infarct size—provided there is also reperfusion!—in all species tested so far, including man.11–15 Although the phenomena of ischaemic pre- and postconditioning have stimulated research on the pathobiology of myocardial ischaemia and reperfusion in general, and notably on endogenous protective signalling mechanisms,12,16 their value has thus far remained mostly paradigmatic. The translation of experimental findings to patients with acute myocardial infarction has remained somewhat inferential for ischaemic preconditioning11 and has been limited to small-scale proof-of-concept . . . [Full Text of this Article]


   1. Coronary microembolization prior to acute myocardial infarction
 

   2. Incomplete reperfusion following acute myocardial infarction
 

   3. Interference of cardioprotective signalling with coronary artery disease and its treatment
 

   Funding
 

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G. Heusch, P. Kleinbongard, D. Bose, B. Levkau, M. Haude, R. Schulz, and R. Erbel
Coronary Microembolization: From Bedside to Bench and Back to Bedside
Circulation, November 3, 2009; 120(18): 1822 - 1836.
[Abstract] [Full Text] [PDF]