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Cardiovascular Research Advance Access originally published online on June 6, 2008
Cardiovascular Research 2008 79(3):353-354; doi:10.1093/cvr/cvn152
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Oestrogen plays a permissive role in cardioprotection

Michael V. Cohen1,2,* and James M. Downey1

1 Department of Physiology, College of Medicine, University of South Alabama, MSB 3050, Mobile, AL 36688, USA
2 Department of Medicine, College of Medicine, University of South Alabama, Mobile, AL, USA

* Corresponding author. Tel: +1 251 460 6812; fax: +1 251 460 6386. E-mail address: mcohen@usouthal.edu

This editorial refers to ‘Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C {epsilon} phosphorylation’ by K. Shinmura et al.,1 pp. 387–394, this issue.

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Ischaemic preconditioning (IPC) is a powerful cardioprotective intervention. It can salvage upwards of 75% of the myocardium destined to otherwise infarct. This potent cardioprotective strategy has been observed in all animal species examined to date including mammals and birds.1 We have observed IPC's protection in non-human primates (unpublished observation) and strong evidence exists of its efficacy in man.2,3 Since the initial description of IPC in 1986 by Murry et al.,4 many investigators have toiled to uncover its mechanism in the hopes of being able to apply the strategy clinically. As a result, much . . . [Full Text of this Article]


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Loss of ischaemic preconditioning in ovariectomized rat hearts: possible involvement of impaired protein kinase C {varepsilon} phosphorylation
Ken Shinmura, Maiko Nagai, Kayoko Tamaki, and Roberto Bolli
Cardiovasc Res 2008 79: 387-394. [Abstract] [Full Text] [PDF]