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Cardiovascular Research Advance Access originally published online on November 11, 2008
Cardiovascular Research 2009 81(1):7-8; doi:10.1093/cvr/cvn305
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

The origin of intimal smooth muscle cells: are we on a steady road back to the past?

Bart De Geest*

Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, Herestraat 49, Leuven 3000, Belgium

* Corresponding author. Tel: +32 16 33 0578; fax: +32 16 34 5990. E-mail address: bart.degeest@med.kuleuven.be

This editorial refers to ‘The origin of post-injury neointimal cells in the rat balloon injury model’ by Rodriguez-Menocal et al.,1 pp. 46–53, this issue.

The first 10% of the full text of this article appears below.

The origin of intimal smooth muscle cells in native atherosclerosis, post-injury neointima formation, allograft vasculopathy, and vein graft atherosclerosis has been the subject of a confusing literature in the past decade. Rodriguez-Menocal et al.1 show in an elegant series of experiments that neointimal cells in a rat balloon injury model originate from pre-existing vascular cells and only rarely come from circulating progenitor cells derived from the bone marrow or from other sources. Two different experimental approaches in an inbred strain of rats lead to essentially the same conclusions. First, the authors performed balloon angioplasty experiments in the right iliac artery of chimeric rats rescued following lethal irradiation with bone marrow from syngeneic transgenic rats expressing green fluorescent protein (GFP) under the control of a ubiquitously active . . . [Full Text of this Article]


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The origin of post-injury neointimal cells in the rat balloon injury model
Luis Rodriguez-Menocal, Melissa St-Pierre, Yuntao Wei, Sheik Khan, Dania Mateu, Marian Calfa, Amir A. Rahnemai-Azar, Gary Striker, Si M. Pham, and Roberto I. Vazquez-Padron
Cardiovasc Res 2009 81: 46-53. [Abstract] [Full Text] [PDF]