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Cardiovascular Research Advance Access originally published online on September 10, 2008
Cardiovascular Research 2008 80(2):163-164; doi:10.1093/cvr/cvn245
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Activating SIRT1: a new strategy to prevent atherosclerosis?

Ralf P. Brandes*

Institut für Kardiovaskuläre Physiologie, Goethe-Universität, Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany

* Corresponding author. Tel: +49 69 6301 6995; fax: +49 69 6301 7668. E-mail address: r.brandes@em.uni-frankfurt.de

This editorial refers to ‘Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice’ by Zhang et al.,8 pp. 191–199, this issue.

The first 10% of the full text of this article appears below.

The development of atherosclerosis is a complex, multi-step process, which is at least in part controlled by the functional state of the vascular endothelium. It is generally believed that the functional state of the endothelium is influenced by a broad set of cardiovascular risk factors and that endothelial dysfunction is the stereotypic cellular response to a broad range of different stimuli on the background of a poorly defined genetic predisposition.1

That such a concept represents an over-simplification . . . [Full Text of this Article]


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Endothelium-specific overexpression of class III deacetylase SIRT1 decreases atherosclerosis in apolipoprotein E-deficient mice
Qing-jun Zhang, Zhao Wang, Hou-zao Chen, Shuang Zhou, Wei Zheng, Guang Liu, Yu-sheng Wei, Hua Cai, De-pei Liu, and Chih-chuan Liang
Cardiovasc Res 2008 80: 191-199. [Abstract] [Full Text] [PDF]