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Cardiovascular Research Advance Access originally published online on February 15, 2008
Cardiovascular Research 2008 78(1):3-4; doi:10.1093/cvr/cvn044
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org.

Toll-like receptors and myocardial contractile dysfunction

Toshiyuki Takahashi*

Department of Cardiology, JR Tokyo General Hospital, 2-1-3 Yoyogi, Shibuya-ku, Tokyo 151-8528, Japan

* Corresponding author. Tel: +81 3 3320 2200; fax: +81 3 3370 8501. E-mail address: toshitak-tky@umin.ac.jp

The first 10% of the full text of this article appears below.

Editorial commentary on ‘Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of Toll-like receptor 9.’ (Knuefermann et al.,9 pp. 26–35, this issue).

Toll-like receptors (TLRs), vertebrate homologues of the drosophila Toll receptor, have been shown to play essential roles in the innate immune response.1 As TLRs recognize pathogen-associated molecular patterns (PAMPs), they are also known as pattern recognition receptors (PRRs). So far, 11 members of human TLRs have been identified.1 Roles of TLRs have been vigorously studied also in the area of cardiovascular sciences, and these molecules are responsible for the genesis of a variety of cardiovascular disorders, including myocardial dysfunction during . . . [Full Text of this Article]


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Related articles in Cardiovasc Res:

Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of Toll-like receptor 9
Pascal Knuefermann, Markus Schwederski, Markus Velten, Peter Krings, Heidi Ehrentraut, Myriam Rüdiger, Olaf Boehm, Klaus Fink, Ulrike Dreiner, Christian Grohé, Andreas Hoeft, Georg Baumgarten, Alexander Koch, Kai Zacharowski, and Rainer Meyer
Cardiovasc Res 2008 78: 26-35. [Abstract] [FREE Full Text]  

Related Article

Bacterial DNA induces myocardial inflammation and reduces cardiomyocyte contractility: role of Toll-like receptor 9
Pascal Knuefermann, Markus Schwederski, Markus Velten, Peter Krings, Heidi Ehrentraut, Myriam Rüdiger, Olaf Boehm, Klaus Fink, Ulrike Dreiner, Christian Grohé, Andreas Hoeft, Georg Baumgarten, Alexander Koch, Kai Zacharowski, and Rainer Meyer
Cardiovasc Res 2008 78: 26-35. [Abstract] [Full Text] [PDF]