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Cardiovascular Research Advance Access originally published online on May 8, 2009
Cardiovascular Research 2009 83(1):1-2; doi:10.1093/cvr/cvp145
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Beyond tie-ing up endothelial adhesion: new insights into the action of angiopoietin-1 in regulation of microvessel permeability

Pingnian He*

Department of Physiology and Pharmacology, School of Medicine, West Virginia University, Morgantown, WV 26506-9229, USA

* Corresponding author. Tel: +1 304 293 1515; fax: +1 304 293 3850. E-mail address: phe@hsc.wvu.edu

This editorial refers to ‘Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx’ by A.H.J. Salmon et al.,6 pp. 24–33, this issue.

The first 10% of the full text of this article appears below.

The growth factor angiopoietin-1 (Ang1) has been identified as the primary activating ligand for Tie2, a tyrosine kinase receptor highly expressed in vascular endothelial cells.1 Genetic studies using targeted mutations in mice have demonstrated that Tie2 activation by Ang1 is crucial for angiogenesis, vascular remodelling, and vascular maturation.2 However, the angiogenic functions of Ang1 are distinct from those of vascular endothelial growth factor (VEGF). Transgenic mice studies have revealed that blood vessels induced by VEGF overexpression are leaky, whereas blood vessels induced by Ang1 overexpression are not only non-leaky, but also resistant to vascular leakage during inflammation.3 Previous studies . . . [Full Text of this Article]


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Related Article

Angiopoietin-1 alters microvascular permeability coefficients in vivo via modification of endothelial glycocalyx
Andrew H.J. Salmon, Christopher R. Neal, Leslie M. Sage, Catherine A. Glass, Steven J. Harper, and David O. Bates
Cardiovasc Res 2009 83: 24-33. [Abstract] [Full Text] [PDF]