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Cardiovascular Research Advance Access originally published online on January 15, 2009
Cardiovascular Research 2009 81(4):629-632; doi:10.1093/cvr/cvp013
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org

Cytochromes CYP1A1 and CYP1B1: new pieces in the puzzle to understand the biomechanical paradigm of atherosclerosis

Raffaele De Caterina* and Rosalinda Madonna

Institute of Cardiology and Center of Excellence on Aging, G. d'Annunzio University – Chieti, C/o Ospedale SS. Annunziata, Via dei Vestini, 66013 Chieti, Italy

* Corresponding author. Tel: +39 0871 415 12; fax: +39 0871 402 817. E-mail: rdecater@unich.it

This editorial refers to ‘Expression of CYP1A1 and CYP1B1 in human endothelial cells: Regulation by fluid shear stress’ by D.E. Conway et al.,6 pp. 669–677, this issue.

The first 150 words of the full text of this article appear below.

Atherosclerosis is epidemiologically linked and causally related to the presence of ‘risk factors’. Despite their diversity, major risk factors for cardiovascular disease such as hypercholesterolaemia, diabetes, hypertension, physical inactivity, obesity, and tobacco smoking share a common ‘systemic’ mechanism of action, i.e. they act on the entire inner surface of the arterial vascular tree. The cellular and molecular effects of such systemic risk factors, acting through biohumoral mediators, can account for the greater or lesser propensity of different individuals to atherosclerotic vascular disease (the ‘biohumoral’ paradigm).1,2 Atherosclerosis is, however, focal and discrete in location and has clear preferences for certain sites of the vasculature, such as branching points, bifurcations, or the convex side of curved arteries. In addition, some arteries are more prone to atherosclerosis than others (e.g. the carotid artery vs. the subclavian artery, epicardial coronary arteries vs. intramyocardial arteries), and there are preferential locations even within extremely close areas . . . [Full Text of this Article]


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Expression of CYP1A1 and CYP1B1 in human endothelial cells: regulation by fluid shear stress
Daniel E. Conway, Yumiko Sakurai, Daiana Weiss, J. David Vega, W. Robert Taylor, Hanjoong Jo, Suzanne G. Eskin, Craig B. Marcus, and Larry V. McIntire
Cardiovasc Res 2009 81: 669-677. [Abstract] [Full Text] [PDF]