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Cardiovascular Research Advance Access originally published online on August 27, 2009
Cardiovascular Research 2009 84(2):173-175; doi:10.1093/cvr/cvp298
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

No RISK, no ... cardioprotection? A critical perspective

Gerd Heusch*

Institut für Pathophysiologie, Universitätsklinikum Essen, Hufelandstr. 55, 45122 Essen, Germany

* Corresponding author. Tel: +49 201 723 4480; fax: +49 201 723 4481; E-mail address: gerd.heusch@uk-essen.de

This editorial refers to ‘Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway’ by L. Lacerda et al., pp. 201–208, this issue.

The first 10% of the full text of this article appears below.

Early reperfusion is today's gold standard therapy for acute myocardial infarction. The underlying fundamental experiments that demonstrated salvage of myocardial tissue after prolonged coronary occlusion were published less than 4 decades ago1,2 and then subsequently confirmed in large-scale clinical trials such as the GISSI trial and many others. The notion that reperfusion may not only salvage infarcting myocardium but also induce damage itself dates back almost as long.3,4 The awareness of such potential reperfusion injury and the ambivalent character of reperfusion5 prompted the search for strategies to modify reperfusion. Of note, modalities to avoid immediate full restoration of blood flow and to . . . [Full Text of this Article]


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Ischaemic postconditioning protects against reperfusion injury via the SAFE pathway
Lydia Lacerda, Sarin Somers, Lionel H. Opie, and Sandrine Lecour
Cardiovasc Res 2009 84: 201-208. [Abstract] [Full Text] [PDF]