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Cardiovascular Research Advance Access originally published online on April 8, 2009
Cardiovascular Research 2009 82(3):385-387; doi:10.1093/cvr/cvp114
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2009. For permissions please email: journals.permissions@oxfordjournals.org.

Enhancing cardiac stem cell differentiation into cardiomyocytes

Steven A.J. Chamuleau, Eric van Belle and Pieter A. Doevendans*

Department of Cardiology, University Medical Center, Heidelberglaan 100, room E03-511, 3584 CX Utrecht, The Netherlands

* Corresponding author. Tel: +31 88 7559801; fax: +31 30 2516396. E-mail address: p.doevendans@umcutrecht.nl

This editorial refers to ‘Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields’ by R. Gaetani et al.,3 pp. 411–420, this issue.

The first 10% of the full text of this article appears below.

Myocardial infarction results in the loss of cardiomyocytes, scar formation, ventricular remodelling, and eventually heart failure. In recent years, cell therapy has emerged as a potential new strategy for patients with ischaemic heart disease. Cell therapy potentially includes embryonic and bone marrow-derived stem cells.1 Recently, the existence of cardiac stem cells that reside in the heart itself was demonstrated. The discovery of cardiac stem cells has sparked intense hope for myocardial regeneration with cells that are obtained from the heart itself and are thereby inherently programmed to reconstitute cardiac tissue. These cardiac stem cells can be detected by several surface markers (e.g. c-kit, Sca-1, MDR1, and . . . [Full Text of this Article]


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Differentiation of human adult cardiac stem cells exposed to extremely low-frequency electromagnetic fields
Roberto Gaetani, Mario Ledda, Lucio Barile, Isotta Chimenti, Flavia De Carlo, Elvira Forte, Vittoria Ionta, Livio Giuliani, Enrico D'Emilia, Giacomo Frati, Fabio Miraldi, Deleana Pozzi, Elisa Messina, Settimio Grimaldi, Alessandro Giacomello, and Antonella Lisi
Cardiovasc Res 2009 82: 411-420. [Abstract] [Full Text] [PDF]