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Cardiovascular Research Advance Access originally published online on December 16, 2008
Cardiovascular Research 2009 81(2):237-239; doi:10.1093/cvr/cvn345
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Vascular smooth muscle cells sense calcium: a new paradigm in vascular calcification

Rhian M. Touyz* and Augusto C. Montezano

Kidney Research Centre, Research Institute, University of Ottawa/Ottawa Health, 451 Smyth Rd, Ottawa, ON, KIH 8M5 Canada

* Corresponding author. Tel: +1 613 562 5800; fax: +1 613 562 5487. E-mail address: rtouyz@uottawa.ca

This editorial refers to ‘Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells’ by Alam et al.,10 pp. 260–268, this issue.

The first 10% of the full text of this article appears below.

Calcification of arteries is a complex and dynamic process frequently seen in atherosclerosis, diabetes, and chronic kidney disease. This phenomenon, now considered a distinct inflammatory arteriopathy, has important clinical significance because arterial calcification is associated with increased cardiovascular events and is a strong predictor of poor cardiovascular outcomes.1,2 Patients with high coronary artery calcification scores have a five- to seven-fold increase in the risk of a hard coronary event compared with patients with low calcium scores, and patients with chronic kidney disease and vascular calcification have a 20- to 30-fold increase in cardiovascular mortality.2

Arterial calcification is a pathological process involving the vascular media . . . [Full Text of this Article]


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Calcification is associated with loss of functional calcium-sensing receptor in vascular smooth muscle cells
Masih-ul Alam, John Paul Kirton, Fiona L. Wilkinson, Emily Towers, Smeeta Sinha, Mansour Rouhi, Thomas N. Vizard, Andrew P. Sage, David Martin, Donald T. Ward, Marie Yvonne Alexander, Daniela Riccardi, and Ann E. Canfield
Cardiovasc Res 2009 81: 260-268. [Abstract] [Full Text] [PDF]