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Cardiovascular Research Advance Access originally published online on December 15, 2008
Cardiovascular Research 2009 81(2):235-236; doi:10.1093/cvr/cvn347
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Published by Oxford University Press on behalf of the European Society of Cardiology 2008

Hearty slices to plan for future health

Brenda Russell1,2,* and John M. Collins2

1 Department of Physiology and Biophysics (M/C 901), University of Illinois at Chicago, 835 S. Wolcott Avenue, Chicago, IL 60612-7342, USA
2 Department of Bioengineering, University of Illinois at Chicago, 835 S. Wolcott Avenue, Chicago, IL 60612-7342, USA

* Corresponding author. Tel: +1 312 413 0407; fax: +1 312 996 6312. E-mail address: russell@uic.edu

This editorial refers to ‘An in vitro beating heart model for long-term assessment of experimental therapeutics’ by W. Habeler et al.,6 pp. 253–259, this issue.

The first 10% of the full text of this article appears below.

Clinical trials have shown that heart function can only be moderately improved by injection of stem cells.1,2 Gains to date are most likely the result of increased wall stiffness and angiogenesis rather than generation of new, beating myocytes.3–5 Poor results could be due to the number and kind of cells used, the timing and method of delivery, lack of engraftment in an inhospitable local environment, general immune responses, and many more variables. Thus, although the current approach has been responsive to public pressure to rush to translate new ideas to a cure, the lack of . . . [Full Text of this Article]


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Related Article

An in vitro beating heart model for long-term assessment of experimental therapeutics
Walter Habeler, Séverine Pouillot, Alexandra Plancheron, Michel Pucéat, Marc Peschanski, and Christelle Monville
Cardiovasc Res 2009 81: 253-259. [Abstract] [Full Text] [PDF]