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Cardiovascular Research Advance Access originally published online on November 11, 2008
Cardiovascular Research 2009 81(1):5-6; doi:10.1093/cvr/cvn307
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

PP2A: a new link between peroxynitrite and endothelial barrier dysfunction?

Qin Wang*

The Tumor Immunology Laboratory, Division of Surgical Oncology, Department of Surgery, 630 West 168th Street, P&S 17-508, Columbia University, New York, NY 10032, USA

* Corresponding author. Tel: +1 212 342 0237; fax: +1 212 305 5337. E-mail address: qw2109@columbia.edu

This editorial refers to ‘Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction’ by Wu and Wilson,1 pp. 38–45, this issue.

The first 10% of the full text of this article appears below.

Recent studies have identified many important signalling pathways that regulate endothelial cell (EC) barrier functions during physiological and pathological conditions. Understanding how these signalling pathways target their downstream effectors and thereby coordinate changes in EC cytoskeleton, junctional adhesion molecules and integrins to regulate EC barrier functions has been the focus of many recent studies. An interesting study by Wu and Wilson addresses the role of protein phosphatase 2A (PP2A) in regulating microvascular EC barrier dysfunction induced by LPS plus interferon (IFN{gamma}).1 The authors used mouse skeletal microvascular ECs and demonstrate that PP2A is . . . [Full Text of this Article]


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Related Article

Peroxynitrite-dependent activation of protein phosphatase type 2A mediates microvascular endothelial barrier dysfunction
Feng Wu and John X. Wilson
Cardiovasc Res 2009 81: 38-45. [Abstract] [Full Text] [PDF]