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Cardiovascular Research Advance Access originally published online on July 9, 2008
Cardiovascular Research 2008 79(4):551-552; doi:10.1093/cvr/cvn189
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

MicroRNAs: components of an integrated system controlling cardiac development, physiology, and disease pathogenesis

Gianluigi Condorelli1,2,* and Stefanie Dimmeler3

1 Division of Cardiology, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, San Diego, CA 92093-0641, USA
2 Scientific and Technology Pole, Istituto di Ricovero e Cura a Carattere Scientifico Multimedica, Via Fantoli 16/15, Milan 20138, Italy
3 Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, Theodor-Stern-Kai 7, 60590 Frankfurt, Germany

* Corresponding author. Tel: +1 8585343347; fax: +1 8585343347. E-mail address: gconorelli@ucsd.edu

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See reviews in this series by Fazi and Nervi,21 Thum et al.,22 Yang et al.,23 and Urbich et al.24

Protein-encoding sequences comprise <1.5% of the human genome.1 Nevertheless, a considerable fraction (~90%) of the genome is effectively transcribed.2 Therefore, most of the transcriptional output of the genome of higher organisms seems to consist of non-coding (nc) RNAs, i.e. RNA that is not translated into a protein end product.3 It is now clear that much of this genomic output is not just transcriptional background noise of ‘junk’ DNA but an intricate RNA-based network constituting a level of regulation that appears as important . . . [Full Text of this Article]


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