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Cardiovascular Research Advance Access originally published online on July 2, 2008
Cardiovascular Research 2008 79(4):545-546; doi:10.1093/cvr/cvn186
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Sarcolemmal permeability changes during ischaemia and reperfusion: release of survival factors

Amanda Lochner*

Department Biomedical Sciences, Division of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, PO Box 19063, Tygerberg, Republic of South Africa

* Corresponding author. Tel: +27 21 938 9391; fax: +27 21 938 9476. E-mail address: alo@sun.ac.za

This editorial refers to ‘Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion’ by Y. Mizukami et al.,14 pp. 589–599, this issue.

The first 10% of the full text of this article appears below.

Enzyme release by ischaemic myocardium has been used as a hallmark of the infarction process for several decades: in the clinical setting, deterioration of cell membrane integrity, as evidenced by the release of macromolecules such as creatine kinase and lactate dehydrogenase, has been used as quantitative indication of myocardial infarction. Leakage of membrane-impermeable molecules due to sarcolemmal rupture is considered to be the most prominent feature of irreversible injury, and the main mechanisms proposed to underlie this phenomenon are energy deficiency and calcium overload.1,2 However, changes in sarcolemmal permeabililty have been demonstrated to occur after exposure of the heart to relatively short periods of ischaemia. Using NMR spectroscopy, Askenasy et al.3 showed that sarcolemmal integrity deteriorated as a function of the duration . . . [Full Text of this Article]


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Related Article

Identification and physiological activity of survival factor released from cardiomyocytes during ischaemia and reperfusion
Yoichi Mizukami, Kyoichi Ono, Cheng-Kun Du, Toshihiko Aki, Naoya Hatano, Yosuke Okamoto, Yasuhiro Ikeda, Hiroshi Ito, Kimikazu Hamano, and Sachio Morimoto
Cardiovasc Res 2008 79: 589-599. [Abstract] [Full Text] [PDF]