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Cardiovascular Research Advance Access originally published online on May 28, 2008
Cardiovascular Research 2008 79(3):355-356; doi:10.1093/cvr/cvn132
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Towards the second generation of skeletal myoblasts?

Philippe Menasché*

Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Department of Cardiovascular Surgery; University Paris Descartes, Faculté de Médecine; INSERM U 633, Paris, France

* Corresponding author. Tel: +33 1 56 09 29 62; fax: +33 1 56 09 22 19. E-mail address: philippe.menasche@hop.egp.ap-hop-paris.fr

This editorial refers to ‘Colony-stimulating factor-1 transfection of myoblasts improves the repair of failing myocardium following autologous myoblast transplantation’ by S. Aharinejad et al.,3 pp. 395–404, this issue.

The first 10% of the full text of this article appears below.

It is now widely accepted that the putative benefits of cell transplantation are hampered by the high rate of cell death that occurs shortly after the procedure. While this event may not be so relevant to bone-marrow-derived cellular grafts whose efficacy seems to depend on cell functionality rather than on the absolute numbers of delivered cells,1 such is not the case for skeletal myoblasts for which a dose-effect relationship has been demonstrated.2 It thus appears to be sound to speculate that outcomes of myoblast transplantation could be improved if cell survival was enhanced.

Although post-delivery cell death is a complex phenomenon which involves several intricate factors, three of them have been . . . [Full Text of this Article]


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Related articles in Cardiovasc Res:

Colony-stimulating factor-1 transfection of myoblasts improves the repair of failing myocardium following autologous myoblast transplantation
Seyedhossein Aharinejad, Dietmar Abraham, Patrick Paulus, Karin Zins, Michael Hofmann, Wolfgang Michlits, Mariann Gyöngyösi, Karin Macfelda, Trevor Lucas, Karola Trescher, Michael Grimm, and E. Richard Stanley
Cardiovasc Res 2008 79: 395-404. [Abstract] [FREE Full Text]  

Related Article

Colony-stimulating factor-1 transfection of myoblasts improves the repair of failing myocardium following autologous myoblast transplantation
Seyedhossein Aharinejad, Dietmar Abraham, Patrick Paulus, Karin Zins, Michael Hofmann, Wolfgang Michlits, Mariann Gyöngyösi, Karin Macfelda, Trevor Lucas, Karola Trescher, Michael Grimm, and E. Richard Stanley
Cardiovasc Res 2008 79: 395-404. [Abstract] [Full Text] [PDF]



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B. J. Gersh, R. D. Simari, A. Behfar, C. M. Terzic, and A. Terzic
Cardiac Cell Repair Therapy: A Clinical Perspective
Mayo Clin. Proc., October 1, 2009; 84(10): 876 - 892.
[Abstract] [Full Text] [PDF]