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Cardiovascular Research Advance Access originally published online on May 16, 2008
Cardiovascular Research 2008 79(1):5-6; doi:10.1093/cvr/cvn109
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Published by Oxford University Press on behalf of the European Society of Cardiology 2008

Heart-rate reduction and β-blockade in early post-infarction cardiac remodelling

Robert E. Goldstein* and Mark C.P. Haigney

Cardiology Division, Department of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814-4799, USA

* Corresponding author. Tel: +1 301 295 3601; fax: +1 301 295 3557. E-mail address: rgoldstein@usuhs.mil

This editorial refers to ‘Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart’ by M. Maczewski and U. Mackiewicz, pp. 42–51,6 this issue.

The first 10% of the full text of this article appears below.

Soon after acute myocardial infarction, the heart may experience extensive changes in function, structure, tissue architecture, and biochemical properties collectively known as cardiac remodelling. Many of the deleterious changes can be attenuated by treatment with β-adrenergic blocking agents1–3 or with alternative drugs that reduce post-infarction heart rate without interrupting β-adrenergic signalling.4,5 In a study appearing in this issue of Cardiovascular Research,6 Maczewski and Mackiewicz employed a rat model to elucidate the benefits of post-infarction β-blockade by comparing effects of heart-rate reduction without β-blockade (using ivabradine) and effects observed when the same reduction in heart rate was combined . . . [Full Text of this Article]


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Related articles in Cardiovasc Res:

Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart
Michal Maczewski and Urszula Mackiewicz
Cardiovasc Res 2008 79: 42-51. [Abstract] [FREE Full Text]  

Related Article

Effect of metoprolol and ivabradine on left ventricular remodelling and Ca2+ handling in the post-infarction rat heart
Michal Maczewski and Urszula Mackiewicz
Cardiovasc Res 2008 79: 42-51. [Abstract] [Full Text] [PDF]