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Cardiovascular Research Advance Access originally published online on April 5, 2008
Cardiovascular Research 2008 78(3):411-412; doi:10.1093/cvr/cvn092
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2008. For permissions please email: journals.permissions@oxfordjournals.org

Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis

Dobromir Dobrev* and Erich Wettwer

Department of Pharmacology and Toxicology, Dresden University of Technology, Fetscher Str 74, 01307 Dresden, Germany

* Corresponding author. Tel: +49 351 458 6279; fax: +49 351 458 6315. E-mail address: dobrev@rcs.urz.tu-dresden.de

This editorial is linked to the article ‘Four and a half LIM protein 1: a partner of KCNA5 in human atrium’ by Z. Yang et al.,7 pp. 449–457, this issue.

The first 10% of the full text of this article appears below.

Chronic atrial diseases are associated with electrical, mechanical, and structural changes (remodelling) that result from activation of diverse signal transduction pathways. In atrial fibrillation (AF), the high atrial rate abbreviates the atrial action potential duration primarily by reduced ICa,L and increased inward-rectifier K+ currents like the background current (IK1) and a constitutively active form of the acetylcholine-dependent K+ current (IK,ACh).1,2 There is also evidence for AF-associated reduction in the ultra-rapid delayed-rectifier IKur, although the reported findings have been inconsistent and the underlying molecular mechanisms are less clear.1 Response rate to antiarrhythmic . . . [Full Text of this Article]


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Related articles in Cardiovasc Res:

Four and a half LIM protein 1: a partner for KCNA5 in human atrium
Zhenjiang Yang, Carrie F. Browning, Haifa Hallaq, Liudmila Yermalitskaya, Jan Esker, Matthew R. Hall, Andrew J. Link, Amy-Joan L. Ham, Meagan J. McGrath, Christina A. Mitchell, and Katherine T. Murray
Cardiovasc Res 2008 78: 449-457. [Abstract] [FREE Full Text]  

Related Article

Four and a half LIM protein 1: a partner for KCNA5 in human atrium
Zhenjiang Yang, Carrie F. Browning, Haifa Hallaq, Liudmila Yermalitskaya, Jan Esker, Matthew R. Hall, Andrew J. Link, Amy-Joan L. Ham, Meagan J. McGrath, Christina A. Mitchell, and Katherine T. Murray
Cardiovasc Res 2008 78: 449-457. [Abstract] [Full Text] [PDF]