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Cardiovascular Research Advance Access originally published online on December 12, 2007
Cardiovascular Research 2008 77(3):443-444; doi:10.1093/cvr/cvm104
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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2007. For permissions please email: journals.permissions@oxfordjournals.org

Hypoxia-inducible factor 1{alpha}: a new piece in the preconditioning puzzle

Kirsti Ytrehus*

Department of Medical Physiology, Institute of Medical Biology, Faculty of Medicine, University of Tromsø, 9037 Tromso, Norway

* Corresponding author. Tel: +47 77 644 781; fax: +47 77 645 440. E-mail address: Kirsti.ytrehus@fagmed.uit.no

The first 10% of the full text of this article appears below.

Ischaemic preconditioning has proved to be a unique tool for revealing the role of intracellular signal transduction in cell survival of ischaemic heart muscle.1 Downey and co-workers proposed the existence of a sequence of events involving a trigger, mediators, and end effect(s) that are able to delay the progression of cell death.2 By using pharmacological preconditioning protocols, a set of cell membrane receptors that stimulate cell survival signalling have been identified, and use of specific kinase inhibitors has enabled further identification of the key signalling pathways.3,4 With the development of transgenic mice models, a new set of tools for investigation of mechanisms controlling the progression of cell death in the heart are available.

True ischaemic preconditioning, or . . . [Full Text of this Article]


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