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Cardiovascular Research 2007 76(2):197-198; doi:10.1016/j.cardiores.2007.08.014
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Copyright © 2007, European Society of Cardiology

Endothelin enhances activity of mechanosensitive channels: A mechanism for ET augmentation of the myogenic response

Harold A. Coleman* and Helena C. Parkington

Department of Physiology, Monash University, Melbourne, Victoria 3800, Australia

*Corresponding author. Tel.: +61 3 9905 2520; fax: +61 3 9905 2547. h.coleman@med.monash.edu.au

Received 22 August 2007; accepted 29 August 2007

The first 10% of the full text of this article appears below.

See article by Lee et al. [11] (pages 224–235) in this issue.

That stretching smooth muscle can result in contraction has been appreciated for over a hundred years (see [1]), and Bayliss in 1902 [1] demonstrated that an increase in luminal pressure in arteries resulted in passive distension followed by constriction. Neural and hormonal mechanisms were excluded, so mechanisms intrinsic to smooth muscle were invoked to explain this phenomenon, now known as the myogenic response. Reports of stretch-induced activation of depolarization[2] and action potentials [3] in visceral smooth muscle were followed by studies on blood vessels in which increases in luminal pressure were associated with depolarization [4–6] and the initiation . . . [Full Text of this Article]


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