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Cardiovascular Research 2007 76(2):195-196; doi:10.1016/j.cardiores.2007.08.011
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Copyright © 2007, European Society of Cardiology

PEDF, PPAR-{delta}, p53: Deadly circuits arise when worlds collide

Carlo Gaetano*, Claudia Colussi and Maurizio C. Capogrossi

Laboratorio di Patologia Vascolare, Istituto Dermopatico dell' Immacolata, Via Monti di Creta 104, 00167, Roma, Italy

*Corresponding author. Tel.: +39 0666462431; fax: +39 0666462430. gaetano@idi.it

Received 6 August 2007; accepted 24 August 2007

The first 10% of the full text of this article appears below.

See article by Ho et al. [6] (pages 213–223) in this issue.

The superfamily of serine proteinase inhibitors (serpins) is involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner [1]. The pigment epithelium-derived factor (PEDF) is a 50-kD serpin that lacks inhibitory properties against either serine or cysteine proteinases [2]. PEDF was first identified in 1987 by Tombran-Tink and Johnson in conditioned medium from foetal human retinal pigment epithelium cell cultures (published in 1991 [3]). PEDF has been shown . . . [Full Text of this Article]


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