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Cardiovascular Research 2007 75(3):453-454; doi:10.1016/j.cardiores.2007.06.010
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Copyright © 2007, European Society of Cardiology

Protecting ischemic hearts by modulation of SR calcium handling

Masaya Tanno* and Tetsuji Miura

Sapporo Medical University, Departments of Pharmacology and Internal Medicine, S1 W16, Chuo-ku Sapporo, 060-8556, Japan

* Corresponding author. Tel.: +81 11 611 2111 ex2721; fax: +81 11 644 7958. tannom@sapmed.ac.jp

Received 27 May 2007; accepted 14 June 2007

The first 10% of the full text of this article appears below.

See article by Zhou et al. [4] (pages 487–497) in this issue.

The sarcoplasmic reticulum (SR) plays a crucial role in excitation-contraction coupling by regulating the concentration and distribution of intracellular Ca2+. The functions of the SR are known to be compromised by ischemia/reperfusion, but whether SR dysfunction contributes to Ca2+ overload and injury in cardiomyocytes during ischemia/reperfusion has been controversial for a decade. Studies using isolated cardiomyocytes subjected to simulated ischemia/reperfusion generally support the role of the SR in Ca2+ overload at the time of "reperfusion" [1]. . . . [Full Text of this Article]


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