Copyright © 2007, European Society of Cardiology
On the first paper in Cardiovascular Research: Frequency, force, and beyond
Department of Medicine, School of Medicine, University of California, San Diego, United States
* 8599 Prestwick Drive, La Jolla, California 92037, United States. Tel./fax: +1 858 453 0166. jlross@ucsd.edu
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The force–frequency effect was the subject of the first paper published in the inaugural issue of Cardiovascular Research in 1967 (Ref. [1]; see Fig. 1). As a co-author with a longstanding interest in this topic, I was asked by the managing editor, Elizabeth Martinson to comment on this publication and on other research in which I was involved during that period at the Cardiology Branch of the then National Heart Institute in Bethesda. It was an exhilarating time for those involved in the (some might say somewhat excessive) outpouring of laboratory and clinical research papers. That first Cardiovascular Research publication arose from the then-prevalent interest in studying the strength-interval relations of cardiac muscle, a term which