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Cardiovascular Research 2007 75(1):3-4; doi:10.1016/j.cardiores.2007.04.016
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Copyright © 2007, European Society of Cardiology

The RhoA/Rho kinase pathway in the myocardium

Stephan L.M. Peters* and Martin C. Michel

Department Pharmacology and Pharmacotherapy, Academic Medical Center, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands

* Corresponding author. Tel.: +31 20 5667622. s.l.peters@amc.uva.nl

Received 13 April 2007; accepted 23 April 2007

The first 10% of the full text of this article appears below.

See article by Lin et al. [2] (pages 51–58) in this issue.

The small GTPase RhoA and its downstream target Rho kinase (Rho-associated coiled-coil protein kinase or ROCK) are involved in cell contraction and a variety of other cellular processes via modulation of actin cytoskeletal assembly. Several studies, including investigations in humans, have clearly shown an important pathophysiological role of this pathway in the cardiovascular system and in disease states such as hypertension, heart failure, stroke, and diabetes [1]. The RhoA/ROCK pathway is best described in smooth muscle cells, where it mediates calcium sensitization and thereby enhances and sustains contraction. . . . [Full Text of this Article]


   1. The RhoA/ROCK pathway
 

   2. RhoA/ROCK pathway in vascular cells
 

   3. RhoA/ROCK pathway in the myocardium
 

   4. RhoA/ROCK as potential drug target
 

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