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Cardiovascular Research 2007 74(1):4-5; doi:10.1016/j.cardiores.2007.02.004
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Copyright © 2007, European Society of Cardiology

Chasing sphingosine-1-phosphate, a lipid mediator for cardiomyocyte survival

Qinglin Yang*

Cardiovascular Research Institute, Morehouse School of Medicine, 720 Westview Dr. SW, Atlanta, GA 30310, United States

* Tel.: +1 404 756 5056; fax: +1 404 742 1042. Email address: qyang@msm.edu

Received 5 February 2007; accepted 7 February 2007

The first 10% of the full text of this article appears below.

See article by Tao et al. [5] (pages 56–63) in this issue.

Sphingosine-1-phosphate (S1P) is a sphingolipid metabolite that regulates many essential biological processes in various cells and tissues. S1P may act as an extracellular ligand to specific G protein-coupled S1P receptors (S1P1–5) or as an intracellular second messenger. Sphingosine is derived from cleavage of ceramide by ceramidases in the sphingolipid degradative pathway. It can be catalyzed by sphingosine kinases (SphK1 and 2) into S1P, which is then degraded by a S1P lyase and S1P phosphohydrolases. S1P is most abundant . . . [Full Text of this Article]


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