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Cardiovascular Research 2007 73(4):626-628; doi:10.1016/j.cardiores.2007.01.007
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Copyright © 2007, European Society of Cardiology

Oxidative stress injury during cardiac surgery: How important is it?

David J. Chambers*

Cardiac Surgical Research, The Rayne Institute (King's College London), Guy's and St Thomas' NHS Foundation Trust, St Thomas' Hospital, London SE1 7EH, UK

* Tel.: +44 20 7188 0958; fax: +44 20 7188 3902. Email address: david.chambers@kcl.ac.uk david.chambers@gstt.nhs.uk

Received 5 January 2007; accepted 9 January 2007

The first 10% of the full text of this article appears below.

See article by Milei et al. [11] (pages 710–719) in this issue.

The concept that the reintroduction of oxygen to the ischaemic myocardium causes significant injury has long been known [1], and it is now well-established [2] that oxidative stress is one of the major initiators of myocardial injury during ischaemia and reperfusion. Cardiac surgery for coronary artery bypass generally involves cardiopulmonary bypass with cardioplegic arrest and elective global ischaemia of the heart. It would appear to represent the ideal situation to evaluate the potential injury induced by oxidative stress during ischaemia and subsequent reperfusion, since in this clinical situation (and unusually for most ischaemic conditions) the time of onset and the duration of ischaemia are known as is the time . . . [Full Text of this Article]


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