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Cardiovascular Research 2007 73(1):1-2; doi:10.1016/j.cardiores.2006.11.002
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Copyright © 2006, European Society of Cardiology

Life, death, the unfolded protein response and apoptosis

Anne A. Knowlton*

Molecular and Cellular Cardiology, Cardiovascular Division, University of California, One Shields Avenue, Davis, CA 95616, Davis, CA, United States
Sacramento VA Medical Center, Sacramento, CA, United States

* Molecular and Cellular Cardiology, Cardiovascular Division, University of California, One Shields Avenue, Davis, CA 95616, Davis, CA, United States. Tel.: +1 530 752 5461; fax: +1 530 754 7167. Email address: aaknowlton@ucdavis.edu

Received 30 October 2006; accepted 1 November 2006

The first 10% of the full text of this article appears below.

See article by Nickson et al. [1] (pages 48–56) in this issue.

The unfolded protein response (UPR) occurs in cells in response to accumulation of unfolded proteins in the endoplasmic reticulum (ER). When unfolded protein accumulates secondary to a mild stress, universal protein synthesis is inhibited, but then resumes upon recovery. In contrast, a more severe or persistent stress would lead to apoptosis. UPR has not been extensively studied in the heart, though it has been described recently in association with some disease states such as hypertrophy and ischemia. In the current issue, . . . [Full Text of this Article]


   1. UPR
 

   2. PUMA and apoptosis
 

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