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Cardiovascular Research 2006 71(4):609-611; doi:10.1016/j.cardiores.2006.07.002
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Copyright © 2006, European Society of Cardiology

Much ado about bone marrow stem cells: Role in post-myocardial infarct repair

Ian M.C. Dixon*

Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, Canada
Department of Physiology, University of Manitoba, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6

* Tel.: +1 204 235 3419; fax: +1 204 233 6723. Email address: idixon@sbrc.ca

Received 30 June 2006; accepted 5 July 2006

The first 10% of the full text of this article appears below.

See article by Möllmann et al. [14] (pages 661–671) in this issue.

The apparent lack of regenerative capacity of cardiac myocytes has, until recently, been upheld in a number of carefully conducted studies [1,2]. Indeed, this supposition has long formed the principal obstacle to the dream of directed repair of the myocardium following massive loss of cardiomyocytes after myocardial infarction (MI). Perhaps this is why the field of experimental cardiology was set upon its ear when a number of studies were presented to challenge this basic premise [3,4]. This work supported the hypothesis that multi-potent bone marrow stem cells (BMSC) were able to migrate to . . . [Full Text of this Article]


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