Copyright © 2006, European Society of Cardiology
Transmitting biological information using oxygen: Reactive oxygen species as signalling molecules in cardiovascular pathophysiology
aDepartment of Cardiology, King's College London School of Medicine, Bessemer Road, London SE5 9PJ, UK
bDepartment of Physiology, University of Giessen, Aulweg 129, 35392 Giessen, Germany
* Corresponding author. Tel.: +44 207 346 3865; fax: +44 207 346 4771. Email address: ajay.shah@kcl.ac.uk heinrich.sauer@physiologie.med.uni-giessen.de
Received 17 May 2006; accepted 22 May 2006
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The involvement of reactive oxygen species (ROS) in deleterious processes such as DNA damage and reperfusion injury has long been recognized. More recently, however, it has been appreciated that ROS can specifically modulate diverse intracellular signalling pathways through covalent modifications of target molecules ("redox signalling"), thereby inducing distinct changes in cell phenotype that are important in many physiological and pathophysiological processes [1]. Indeed, some ROS such as H2O2 may be ideally suited to serve as signalling molecules in that they are small, highly diffusible, and rapidly generated and degraded. Despite an exponentially growing amount of information on the sources and mechanisms of ROS generation as well as their degradation by the antioxidant defence system, we are just starting to learn how ROS signalling may function within cells and in a coordinated way within tissues and organs.
The numerous sources of ROS generation, which include the mitochondrial respiratory chain
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