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Cardiovascular Research 2006 71(1):6-7; doi:10.1016/j.cardiores.2006.05.007
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Copyright © 2006, European Society of Cardiology

The cardiac β-adrenoceptors: Where and why?

Joachim Neumann*

Institut für Pharmakologie und Toxikologie, Medizinische Fakultät, Martin-Luther Universität Halle-Wittenberg, Magdeburger Str. 4, 06112 Halle, Germany

* Tel.: +49 345 557 1686; fax: +49 345 557 18 35. Email address: joachim.neumann@medizin.uni-halle.de

Received 2 May 2006; accepted 5 May 2006

The first 10% of the full text of this article appears below.

See article by Boivin et al. [1] (pages 69–78) in this issue.

The family of G-protein-coupled heptahelical receptors are widely distributed in the human body. Of special clinical importance are β-adrenoceptors, which mediate the effects of the sympathetic nervous system. In the heart, they induce, at least to a large extent, the inotropic effects of catecholamines. They confer signals from their ligands to the cell, and this signal transduction process classically runs via G-proteins to downstream effectors. . . . [Full Text of this Article]


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