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Cardiovascular Research 2006 71(1):4-5; doi:10.1016/j.cardiores.2006.05.006
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Copyright © 2006, European Society of Cardiology

The role of endothelin-1 in vascular remodeling in vivo

Masafumi Takahashi*

Division of Cardiovascular Sciences, Department of Organ Regeneration, Shinshu University Graduate School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan

* Tel.: +81 263 37 3194; fax: +81 263 37 2573. Email address: masafumi@sch.md.shinshu-u.ac.jp

Received 2 May 2006; accepted 5 May 2006

The first 10% of the full text of this article appears below.

See article by Dao et al. [4] (pages 61–68) in this issue.

Vascular smooth muscle cells (VSMCs) are a major component of the arterial wall and play a critical role in the development of occlusive vascular lesions. In normal vessels, VSMCs are quiescent, differentiated, and contractile and function to maintain vascular tone and blood pressure. In pathological processes such as the response to vascular injury, VSMCs undergo a phenotypic transition whereby they proliferate, migrate from the medial to the intimal layer, and lead to neointimal formation and subsequent vascular remodeling. These resultant vascular changes contribute to the pathological basis of atherosclerosis and restenosis that occur . . . [Full Text of this Article]


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