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Cardiovascular Research 2006 69(4):784-787; doi:10.1016/j.cardiores.2006.01.008
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Copyright © 2006, European Society of Cardiology

Segregation and integration: Roles played by caveolae and caveolins in the cardiovascular system

Ingrid Fleming*

Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Klinikum der J.W. Goethe-Universität, Theodor-Stern-Kai 7, D-60590 Frankfurt am Main, Germany

* Tel.: +49 69 6301 6972; fax: +49 69 6301 7668. Email address: fleming@em.uni-frankfurt.de

Received 6 January 2006; accepted 10 January 2006

The first 150 words of the full text of this article appear below.

See reviews in the series by Feron and Balligand [15] (pages 788–797), Maguy et al. [21] (pages 798–807), and Hardin and Vallejo [24] (pages 808–815) in this issue and by Mineo and Shaul [26] and Schwencke et al. [30] in next month's issue.

Original articles in the series are by Calaghan and White [16] (pages 816–824) and Shaw et al. [25] (pages 825–835) in this issue.

Over the last two decades our view of the cell membrane has progressed from that of a relatively homogenous protein-containing lipid bilayer that simply separates the cytosol from the extracellular milieu. We now know that the cell membrane is composed of many and varied types of lipids and that their properties largely determine protein localisation and thus protein–protein interactions and cellular signalling. There has also been a veritable explosion of knowledge regarding lipid membrane compartmentalisation, and this Review Focus Series on "Caveolae in Cardiovascular . . . [Full Text of this Article]


   1. Caveolar signalling in the heart
 
2. Regulation of the endothelial nitric oxide synthase (eNOS) in the heart by caveolins
2.1 Ion channels

   3. Caveolar signalling in vascular smooth muscle cells
 
3.1 Caveolae and myogenic tone

   4. Caveolar signalling in disease
 

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